Papaverine, rectal 20 mg 10 pcs

Papaverine hydrochloride is a myotropic antispasmodic agent. It inhibits phosphodiesterase, causes accumulation of cyclic 3,5-adenosine monophosphate (AMP) and decrease of calcium in the cell.

Relaxes smooth muscles of internal organs (gastrointestinal tract, respiratory tract, genitourinary system) and blood vessels.

In high doses it reduces excitability of the heart muscle and slows intracardiac conduction.

The action of papaverine on the central nervous system is weak but in high doses it produces a sedative effect.

Pharmacokinetics

Bioavailability of papaverine after rectal administration (according to preclinical studies) is about 25%. The binding to plasma proteins is 90%. It is well distributed, penetrates through histohematic barriers.

Metabolized in liver. The elimination half-life (T1/2) is 0.5-2 hours (possibly increased up to 24 hours). It is excreted by kidneys as metabolites.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Decreases the effect of dopetite.

The effectiveness decreases with smoking.

Special Instructions

With caution and in low doses should be used in elderly and debilitated patients, as well as in patients with craniocerebral trauma, hepatic and renal disorders, hypothyroidism, insufficient adrenal function, prostatic hypertrophy, supraventricular tachycardia and shock.

Alcohol should be avoided during treatment.

Contraindications

Side effects

Overdose

Symptoms: diplopia weakness decreased blood pressure drowsiness.

Treatment: symptomatic (maintenance of blood pressure).

Pregnancy use