Papaverine, rectal 20 mg 10 pcs

Name: Papaverine, rectal 20 mg 10 pcs
SKU: 70626
Availability: InStock

€4.01

EAN: 4601026004018 SKU: 70626 Categories: Medicine, Pain and fever, Pain and spasms

Description

Papaverine hydrochloride is a myotropic antispasmodic agent. It inhibits phosphodiesterase, causes accumulation of cyclic 3,5-adenosine monophosphate (AMP) and decrease of calcium in the cell.

Relaxes smooth muscles of internal organs (gastrointestinal tract, respiratory tract, genitourinary system) and blood vessels.

In high doses it reduces excitability of the heart muscle and slows intracardiac conduction.

The action of papaverine on the central nervous system is weak but in high doses it produces a sedative effect.

Pharmacokinetics

Bioavailability of papaverine after rectal administration (according to preclinical studies) is about 25%. The binding to plasma proteins is 90%. It is well distributed, penetrates through histohematic barriers.

Metabolized in liver. The elimination half-life (T1/2) is 0.5-2 hours (possibly increased up to 24 hours). It is excreted by kidneys as metabolites.

Indications

Colitis, Urolithiasis, Hypertension (high blood pressure), Pain, Bronchospasm, Gallstone disease, Biliary dyskinesia, Colic

Spasms (severe narrowing of the lumen) of the blood vessels of the brain,
stenocardia,
Endarteritis (inflammation of the inner lining of the arteries,
cholecystitis (inflammation of the gallbladder,
spasm.endarteritis (inflammation of the lining of the arteries),
cholecystitis (inflammation of the gallbladder),
pylorospasm (spasm of the stomach’s gateway muscles),
spastic colitis,
spasm of the urinary tract,
bronchospasm (narrowing of the lumen of the bronchi).

Active ingredient

Papaverine

Composition

Composition per suppository:

Papaverine hydrochloride – 20 mg;

Auxiliary substances:

Solid fat (Vitepsol (grades H 15, W 35)

How to take, the dosage

Rectally. After releasing the suppository from the contoured package, it is inserted into the anus.

One suppository 2 – 3 times a day after spontaneous bowel emptying or purging enema.

Interaction

Decreases the effect of dopetite.

The effectiveness decreases with smoking.

Special Instructions

With caution and in low doses should be used in elderly and debilitated patients, as well as in patients with craniocerebral trauma, hepatic and renal disorders, hypothyroidism, insufficient adrenal function, prostatic hypertrophy, supraventricular tachycardia and shock.

Alcohol should be avoided during treatment.

Contraindications

Hypersensitivity to the components of the drug, atrioventricular block, glaucoma, severe hepatic insufficiency, advanced age (risk of hyperthermia), childhood, since the dosing regimen in children is not indicated.

With caution

With caution and in small doses are used in conditions after craniocerebral injury, chronic renal insufficiency, insufficiency of adrenal function, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock states.

Side effects

Allergic reactions atrioventricular block ventricular extrasystole increased activity of “hepatic” transaminases decreased blood pressure drowsiness constipation eosinophilia.

Overdose

Symptoms: diplopia weakness decreased blood pressure drowsiness.

Treatment: symptomatic (maintenance of blood pressure).

Pregnancy use

Safety of the drug in pregnancy and lactation has not been established. Administration of the drug during pregnancy is possible only by prescription of a physician if the estimated benefits to the mother exceed the potential risk to the fetus and child. Breast-feeding should be suspended during treatment with the drug.

Additional information

Weight	0.022 kg
Shelf life	2 years. Do not use the drug after the expiration date stated on the package.
Conditions of storage	In a dry, light-protected place at a temperature not exceeding 25 °C
Manufacturer	Nizhpharm AO, Russia
Medication form	rectal suppositories
Brand	Nizhpharm AO