Papaverine, 40 mg tablets 20 pcs

Papaverine is a myotropic antispasmodic agent.

It has hypotensive effect.

Inhibits phosphodiesterase, causes accumulation of cyclic 3`,5`-AMP and decrease of calcium in the cell; it reduces tone and relaxes smooth muscles of internal organs (GI, respiratory and urogenital systems) and blood vessels.

Causes dilatation of the arteries, promotes increased blood flow, including cerebral blood flow.

In high doses it reduces excitability of the heart muscle and slows intracardiac conduction.

The action on the CNS is weak, but in high doses it has a sedative effect.

Indications

Active ingredient

Composition

Composition per tablet:

Papaverine hydrochloride – 40 mg

Excipients:

Potato starch – 149.8 mg,

Stearic acid – 2.7 mg,

Saccharose (granulated sugar) – 157.5 mg.

How to take, the dosage

Interaction

Papaverine reduces the antiparkinsonian effect of levodopa and the hypotensive effect of methadone.

In combination with barbiturates the antispasmodic effect of papaverine is increased.

When combined with tricyclic antidepressants procainamide reserpine quinidine, the hypotensive effect of papaverine may be increased.

Special Instructions

The administration of ethanol should be avoided during treatment.

The vasodilating effect of Papaverine is reduced by tobacco smoking.

When prescribing Papaverine to patients with diabetes mellitus it should be noted that the tablet contains sucrose as excipients.

Contraindications

Conditions after cranial trauma chronic renal insufficiency adrenal insufficiency hypothyroidism prostatic hyperplasia supraventricular tachycardia shock pregnancy lactation period (safety not established).

Side effects

Overdose

Symptoms: diplopia weakness decreased blood pressure drowsiness.

Treatment: symptomatic (maintenance of blood pressure).