🐾 Gentamicin 4% solution, 100 ml

Gentamicin has a broad spectrum of antimicrobial action, active against most gram-negative and gram-positive microorganisms, including Proteus, Escherichia, Salmonella and Staphylococcus aureus. The antibiotic has no effect on anaerobic bacteria, fungi and viruses. When administered intramuscularly, the drug penetrates well into many organs and tissues. Maximum concentration in blood is reached 1 hour after injection. After a single injection the therapeutic concentration of the antibiotic in the body is maintained for 8-12 hours. When administered orally the drug is practically not absorbed from the gastrointestinal tract and exerts its effect only in the intestine for 12 hours.  When parenteral administration gentamicin is excreted unchanged mainly with urine, and when administered orally – with feces.  Gentamicin sulfate 4% solution according to GOST 12.1.007-76 refers to Hazard Class 4 – low-hazard substances.

Active ingredient

Gentamicin

Composition

Gentamicin sulfate 4% in 1 ml as an active ingredient contains gentamicin sulfate (in terms of base) – 40 mg, and as excipients: trilon B – 0.1 mg, sodium pyrosulfate – 3.2 mg, as well as water for injections up to 1 ml.

How to take, the dosage

Gentamicin 4% solution for injection is administered intramuscularly in dosage: Cattle, cattle, horses and pigs: 0.5 ml of solution per 10 kg body weight twice a day (2 mg DV per kg body weight twice a day). Dogs and cats: First day – 1.1 ml of the solution per 10 kg body weight twice a day (4.4 mg of DV per kg body weight twice a day); subsequent days – 1.1 ml of the solution per 10 kg body weight once a day. Newborn animals during the first days of life are given only half of the recommended dose. The course of treatment shall be 3-5 days. Gentamicin 4% solution for injection should not be mixed in one syringe with other drugs.

Special Instructions

Slaughter of animals for meat shall be allowed not earlier than 45 days after cessation of drug administration. Meat of animals slaughtered before the specified period can be used to feed fur animals or for production of meat and bone meal. Milk obtained from animals to which gentamicin 4% solution for injection was used shall not be used for human consumption within 3 days after discontinuation of the drug. Such milk can be used for feeding animals.

Contraindications

Renal dysfunction, concomitant use with other nephrotoxic drugs, concomitant use with muscle relaxants and some general anesthetics (chalaton), hypersensitivity to gentamicin, pregnancy. Gentamicin should not be used concomitantly with penicillins, some cephalosporins, other aminoglycoside antibiotics, chloramphenicol, colistin, polymyxin, sulfonamides.

Side effects

Allergic reactions (skin rash, itching, fever). Prolonged use of the drug may cause dysfunction of the eighth cerebral nerve (dogs, cats), also may have harmful effects on the fetus (renal and eighth cerebral nerve dysfunction).