Xylenes, spray 0.1% 15 ml

Xylometazoline belongs to the group of local vasoconstrictors (decongestants) with alpha-adrenomimetic activity.

The drug facilitates nasal breathing by reducing swelling and hyperemia of the mucous membrane and improves discharge of secretions.

The action of the drug starts a few minutes after application and lasts up to 10 hours.

Indications

Acute respiratory diseases with rhinitis (runny nose), acute allergic rhinitis, sinusitis, otitis media (as part of combined therapy to reduce nasopharyngeal mucosal edema), pollinosis, eustachitis, to facilitate rhinoscopy.

Active ingredient

Xylometazoline

Composition

Active ingredient:

Xylometazoline hydrochloride 1.0 mg

Excipients:

Benzalkonium chloride in terms of anhydrous 0.15 mg

Dinatrium edetate dihydrate 0.5 mg

Potassium dihydrophosphate 3,63 mg

Sodium dodecahydrate 7,13 mg

Sodium chloride 9,0 mg

Purified water up to 1,0 ml.

Interaction

Concomitant use of xylometazoline with monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants may lead to increased blood pressure.

Directions for use

Intranasally. Before application it is necessary to clean nasal passages.

Adults and children over 6 years old 1 injection of 0.1% solution of xylometazoline in each nasal passage 2-3 times a day. It should not be used for more than 5-7 days as xylometazoline may cause nasal mucosa edema leading to atrophy.

Children aged from 2 to 6 years old should take 0,05% solution of xylometazoline 1 injection in each nasal passage 1 – 2 times a day. Do not use the drug more than 3 times a day. The duration of drug administration in children is determined by the doctor.

Special Instructions

Prolonged use (more than 7 days) may lead to reactive hyperemia of nasal mucosa and atrophy of nasal mucosa.

Do not exceed the recommended doses. Benzalkonium chloride contained in the drug can cause irritation and swelling of the nasal mucosa.

It is not recommended to use the drug continuously for more than 7 days. Avoid contact of the drug with the eyes

Synopsis

Xylen® Spray 0,1% 15 ml is a vasoconstrictor based on xylometazoline for adults and children over 6 years.

– Helps relieve nasal congestion in 2 minutes after application and up to 12 hours*
– It is indicated for cold and allergic rhinitis, pollinosis and sinusitis.

Xylen® Spray 0,1% 15 ml is suitable for adults and children over 6 years old and helps fight nasal congestion due to a runny nose thus improving nasal breathing.

* According to the instructions for medical use of Xylen® Spray dated 11.06.2021 (RU No.: LP-000748) https://ksilen.expert/
There are CONTRAINDICATIONS. DO CONSULT A SPECIALIST
VER2202162-2 (v2.0) dated 07.10.2021

Contraindications

Hypersensitivity to xylometazoline and other components of the drug, arterial hypertension, tachycardia, marked atherosclerosis, glaucoma, atrophic rhinitis, surgical interventions on the cerebral membranes (in anamnesis), Children under 2 years of age – for 0.05 % solution (0.0005 g/ml), children under 6 years of age – for 0.1 % solution (0.001 g/ml), thyrotoxicosis, conditions after transsphenoidal hypophysectomy, pregnancy.

Do not use during therapy with monoamine oxidase inhibitors and tricyclic antidepressants (including within 14 days after their withdrawal) and with other drugs that increase blood pressure.

With caution
Breast-feeding period, coronary heart disease (angina), diabetes, prostatic hyperplasia, hyperthyroidism, porphyria, pheochromocytoma, patients with hypersensitivity to adrenergic drugs, accompanied by insomnia, dizziness, arrhythmias, tremors, increased blood pressure.

Side effects

With frequent and/or prolonged use – irritation and/or dryness of the nasopharyngeal mucosa, burning, paresthesias, sneezing, hypersecretion; rarely – nasal mucous membrane edema, nasal bleeding, palpitations, tachycardia, arrhythmia, increased blood pressure, nausea, vomiting, headache, insomnia, visual disturbances, depression (with prolonged use of high doses), anxiety, fatigue, hallucinations and seizures (especially in children), hypersensitivity reactions (angioedema, skin rash, itching).

Benzalkonium chloride, which is part of the drug, may cause irritation and swelling of the nasal mucosa.

Overdose

Symptoms:

in overdose or accidental ingestion, the following symptoms may develop: nausea, vomiting, cyanosis, fever, significant decrease in body temperature, shortness of breath, dizziness, increased sweating, headache, bradycardia, arrhythmia, tachycardia, increased blood pressure, which may be followed by lower blood pressure, respiratory depression, coma, seizures. Young children in overdose often have dominant central effects with seizures, coma and bradycardia, apnea, and an increase in blood pressure followed by hypotension.

Treatment:

symptomatic under medical supervision. Observation of the patient should be for several hours. In case of accidental ingestion – gastric lavage, intake of activated charcoal.

Similarities

Atrivin, Galazolin, Xylen, Snoop, Rinonorm, Xymelin Eco, Rinorus, Rinostop, Rinomaris, Xylometazolin, Tisin Classic, Xymelin Eco Menthol, Asterisk, Xyloct, Cold and Flu, Asterisk for Colds, Quatran xylo