Loratadine, tablets 10 mg 10 pcs

Pharmacodynamics

Loratadine is a tricyclic compound with pronounced antihistamine action and is a selective blocker of peripheral H1-histamine receptors. It has a rapid and prolonged antiallergic effect. Onset of action is within 30 minutes after ingestion. Antihistamine effect reaches its maximum after 8-12 hours from the beginning of action and lasts for more than 24 hours.

Pharmacokinetics

Loratadine is quickly and well absorbed in the gastrointestinal tract. Time to reach maximum concentration (Tmax) of loratadine in blood plasma is 1-1.5 hours, and its active metabolite desloratadine – 1.5-3.7 hours. Food intake increases Tmax of loratadine and desloratadine by approximately 1 hour, but has no effect on the effectiveness of the drug.

Indications

• seasonal (pollinosis) and year-round allergic rhinitis, allergic conjunctivitis – elimination of symptoms associated with these diseases: sneezing, nasal mucosa itching, rhinorrhea, burning and itching sensation in the eyes, lacrimation;
• Skin diseases of allergic origin (including chronic idiopathic urticaria);
• allergic reactions to insect bites;
• pseudoallergic reactions.

.

Active ingredient

Loratadine

Composition

The active ingredient:

Loratadine -10.0 mg.

Excipients:

Lactose monohydrate – 71.3 mg

Corn starch – 18.0 mg

Magnesium stearate – 0.7 mg.

How to take, the dosage

• Ingestion, regardless of meals.
• Adults, including the elderly and adolescents over 12 years old, 10 mg (1 tablet) once daily.

Children from 3 to 12 years:

• with a body weight over 30 kg 10 mg (1 tablet) once a day;
• with a body weight under 30 kg 5 mg (½ tablet) once a day.

Adults and children weighing more than 30 kg with severe liver dysfunction should start the dose with 10 mg (1 tablet) once a day.

The duration of treatment depends on the duration of manifestation of symptoms of the disease. If symptoms disappear, the drug should be stopped; if symptoms reappear, the drug should be resumed.

Interaction

• Eating has no effect on the effectiveness of loratadine.
• Loratadine does not potentiate the effects of alcohol on the central nervous system.
• Loratadine co-administration with erythromycin, ketoconazole or cimetidine increases plasma concentrations of loratadine and its active metabolite, but this increase is not clinically significant, including ECG data

.

Contraindications

Hypersensitivity to loratadine and other components of the drug; lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome; breastfeeding period; children under 3 years of age and body weight less than 30 kg.

Side effects

In clinical studies with children aged 2 to 12 years who took loratadine more often than the placebo group (“pacifiers”), headache (2.7%), nervousness (2.3%), fatigue (1%) were observed.

In clinical trials with adults, adverse events observed more often than with placebo were observed in 2% of patients taking loratadine. In adults, headache (0.6%), somnolence (1.2%), increased appetite (0.5%) and insomnia (0.1%) were more frequently observed while using the drug than in the placebo group. In addition, there have been very rare reports (< 1/10,000) of dizziness, fatigue, dry mouth, gastrointestinal disturbances (nausea, gastritis), allergic reactions in the form of rash, anaphylaxis including angioedema, alopecia, impaired liver function, palpitation, tachycardia and seizures in the postmarketing period.

If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Symptoms: headache, drowsiness, tachycardia. In case of overdose seek medical attention immediately.

Treatment: symptomatic and supporting therapy. Possible gastric lavage, taking adsorbents (crushed activated carbon with water).

Loratadine is not excreted by hemodialysis. After acute care, the patient’s condition must be monitored.

Similarities

Claritin, Lomilan, Clarisense, Loragesal, Loratadine, Loratadine Teva, Loratavel