Ibuprofen, gel 5% 50 g

Pharmacotherapeutic group:
Non-steroidal anti-inflammatory drug (NSAID).

ATX code: M02AA13

Pharmacological Properties

The drug belongs to the non-steroidal anti-inflammatory drugs (NSAIDs). It has analgesic and anti-inflammatory effects. It blocks both cyclooxygenases (COX-1 and COX-2) indiscriminately. The mechanism of action is due to the inhibition of the synthesis of prostaglandins – mediators of pain and inflammation.

Pharmacokinetics
The drug is used for topical application only. When applied to the skin, it is detectable in the epidermis and
dermis after 24 hours and is about 5% of the drug concentration when taken orally. Therapeutic concentration is reached
locally, there is no systemic absorption.

Indications

Muscle pain, back pain, arthritis, ligament damage, sprains, sports injuries and neuralgia.

Pharmacological effect

Pharmacotherapeutic group:
non-steroidal anti-inflammatory drug (NSAID).

ATX code: M02AA13

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics
The drug belongs to non-steroidal anti-inflammatory drugs (NSAIDs). Has analgesic and anti-inflammatory effects. Indiscriminately blocks both cyclooxygenases (COX-1 and COX-2). The mechanism of action is due to inhibition of the synthesis of prostaglandins – mediators of pain and
inflammation.

Pharmacokinetics
The drug is used only for topical use. When applied to the skin after 24 hours it is found in the epidermis and
dermis and is about 5% of the drug concentration when taken orally. Therapeutic concentration is achieved
locally, systemic absorption does not occur.

Special instructions

After using the drug, wash your hands thoroughly.

Avoid getting the gel in your eyes and lips. Do not apply the gel to damaged areas of the skin, as well as to the area around the eyes and lips. Do not use in combination with an occlusive (sealed) medical dressing. Avoid excessive sun exposure to the treatment area.

Impact on the ability to drive vehicles and operate machinery

The use of Ibuprofen gel does not affect activities that require increased attention, coordination of movements, high speed of mental and physical (including those of transport drivers, persons servicing cars) reactions.

Active ingredient

Ibuprofen

Composition

Active substance: ibuprofen – 5.0 g.

Excipients: isopropanol – 5.0 g; hyaetellose – 1.8 g; sodium hydroxide – 1.0 g; benzyl alcohol – 1.0 g; water – 86.2 g.

Pregnancy

The drug is prescribed with caution during pregnancy (I-II trimesters) and during breastfeeding. In the later stages
pregnancy (III trimester) the drug is contraindicated.

Contraindications

• hypersensitivity to ibuprofen or other components of the drug, acetylsalicylic acid or other NSAIDs;
• complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history);
• violation of the integrity of the skin at the site of application of the drug (including infected abrasions and wounds, weeping dermatoses, eczema);
• children under 12 years of age;
• pregnancy III trimester.

WITH CAUTION
Use the drug with caution in case of concomitant diseases of the liver or kidneys, gastrointestinal tract; at
bronchial asthma, urticaria, rhinitis, polyps of the nasal mucosa, during pregnancy and lactation.

Side Effects

Hypersensitivity reactions: nonspecific allergic reactions and anaphylactic reactions, reactions from the respiratory tract: asthma (including its exacerbation), bronchospasm, shortness of breath, Quincke’s edema, skin reactions at the site of application of the gel: urticaria, rash, skin hyperemia, burning or tingling sensations. Gastrointestinal disorders following accidental ingestion: abdominal pain, dyspepsia.

With long-term use, systemic side effects of NSAIDs may develop. If side effects occur, you should stop taking the drug and consult a doctor.

Interaction

Drug interactions with ibuprofen in gel form have not been described to date. However, even when applied topically, ibuprofen can have a systemic effect, therefore, theoretically, simultaneous use of the gel with other NSAIDs may lead to increased side effects.

Overdose

The phenomena of overdose with external use have not been established.
If the drug was accidentally taken orally, gastric lavage (only within an hour after administration), activated charcoal, alkaline drinking, forced diuresis, and symptomatic therapy are recommended.

Storage conditions

In a place protected from light at a temperature not exceeding 25 ° C. Keep out of reach of children

Shelf life

3 years. Do not use the drug after the expiration date.

Manufacturer

Ozon, Russia