Nimulide, 100 mg 20 pcs.

How to take, the dosage

Lingual tablet should be placed on the tongue, where it immediately begins to dissolve, then swallow the saliva in which the tablet dissolved.

The maximum daily dose is 200 mg.

Interaction

The effect of drugs that reduce blood clotting is increased when they are used simultaneously with nimesulide.

Nimesulide may reduce the effect of furosemide. Reduces the therapeutic effect of antihypertensive drugs. Nimesulide increases the onset of side effects when concomitant administration of methotrexate.

Plasma lithium levels are increased when concomitant use of lithium and nimesulide.

Nimesulide may increase the nephrotoxic effect of cyclosporine on the kidneys.

The use with glucocorticosteroids, serotonin reuptake inhibitors increases the risk of GI bleeding.

Special Instructions

Nimulide should be used with caution in patients who are prone to bleeding, patients with upper gastrointestinal disorders or patients receiving anticoagulants.

Because Nimulide is partially excreted by the kidneys, its dosage should be reduced for patients with impaired renal function, depending on creatinine clearance values.
Given reports of visual disturbances in patients taking other NSAIDs, treatment should be stopped immediately if any visual disturbance appears, and the patient should be examined by an ophthalmologist.

The drug may cause fluid retention in the tissues, so patients with high blood pressure and with cardiac abnormalities should use Nimulide with extreme caution.

To reduce the risk of gastrointestinal adverse events, use the lowest effective dose for the shortest possible course.
Influence on driving and operating machinery

Patients who have pronounced side effects: dizziness, somnolence, blurred vision should be careful when driving motor transport and engaging in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

• high sensitivity to nimesulide and other components of Nimulide;
• acetylsalicylic acid or other NSAIDs;
• gastric and duodenal ulcers in the acute phase;
• explicit hepatic and renal dysfunction.

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Side effects

Systemic reactions: Heartburn, nausea, vomiting, diarrhea, gastralgia, gastrointestinal mucosal ulceration, headache, dizziness, fluid retention, drowsiness, itching, urticaria, bronchospasm, allergic reactions (skin rash, anaphylactic shock), thrombocytopenia, leukopenia, anemia, agranulocytosis, increased liver transaminase activity, prolonged bleeding time, hematuria.

Local reactions (gel): skin irritation, skin rash, peeling, skin itching, transient change in skin color (not requiring withdrawal of the drug).

Overdose

Symptoms: apathy, drowsiness, nausea, vomiting. Gastrointestinal bleeding, arterial hypertension, acute renal failure, respiratory depression may occur.

Treatment: symptomatic treatment of the patient is required, there is no specific antidote. If overdose occurred within the last 4 hours it is necessary to induce vomiting, provide intake of activated charcoal (60-100 g per adult), osmotic laxatives. Forced diuresis and hemodialysis are ineffective due to high protein binding of the drug.

Pregnancy use

Contraindicated in pregnancy and during lactation.

Similarities

Naiz, Nimesil, Nimesulide, Nemulex, Nimesulide-TEVA, Nimulide, Nimesan tablets 100 mg 20 pcs, Naisulide, Mialais