Pharmacological action – analgesic, antipyretic, anti-inflammatory.
It indiscriminately blocks COX-1 and -2 and has an inhibitory effect on GH synthesis.
The analgesic effect is most pronounced for pain of inflammatory nature. Analgesic activity of the drug does not belong to the narcotic type. It shows antiaggregant activity.
The analgesic effect when using Faspik develops 10-45 min after taking it.
In oral administration it is well absorbed from the gastrointestinal tract.
When using Faspik Cmax ibuprofen in plasma is approximately 25 or 40 µg/mL and is reached approximately 15-30 minutes after an empty stomach dose of 200 or 400 mg, respectively.
It is approximately 99% bound to plasma proteins. Slowly distributed in synovial fluid and excreted more slowly than in plasma.
It is metabolized in the liver mainly by hydroxylation and carboxylation of the isobutyl group. Metabolites are pharmacologically inactive. Has biphasic elimination kinetics. T1/2 from plasma is 1-2 h. Up to 90% of the dose can be detected in the urine as metabolites and their conjugates.
Less than 1% is excreted unchanged in the urine and, to a lesser extent, in the bile.
Back pain, Osteoarthritis and arthritis, Fever, Myalgia (muscle pain), Sore throat, Neck pain, Painful menstruation (algodysmenorrhea), Osteoarthritis, Neuralgia, Rheumatoid arthritis, Headache, Migraine, Joint pain (arthralgia), Infectious diseases, Sciatica, Pain, Colds, Angina, Flu, Toothache, Pain after injuries and operations, Swelling after injuries and operations, Periarthritis, Lumbago
- high fever in various inflammatory diseases
- pain of mild to moderate intensity
- rheumatic diseases.
1 tablet contains ibuprofen 400 mg,
How to take, the dosage
The daily dose of Faspik when taken orally is 0.6-1.2 g in 3-4 doses, the drug is also used in suppositories rectally and ointment externally.
In children, 20-40 mg per kg of weight per day is prescribed.
The efficacy of furosemide and thiazide diuretics may be reduced due to sodium retention associated with inhibition of prostaglandin synthesis in the kidneys.
Faspic may increase the effect of oral anticoagulants, so concomitant use is not recommended.
In concomitant administration with acetylsalicylic acid ibuprofen reduces its antiplatelet effect (the incidence of acute coronary failure may increase in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent).
Faspic may decrease the effectiveness of antihypertensive agents.
The literature has described single cases of increased plasma concentrations of digoxin, phenytoin and lithium with concomitant administration of ibuprofen.
Faspic (like other NSAIDs) should be used with caution in combination with acetylsalicylic acid or other NSAIDs and GCS (this increases the risk of adverse effects of the drug on the GI tract).
Faspic may increase the plasma concentration of methotrexate.
Combination treatment with zidovudine and Faspic may increase the risk of hemarthrosis and hematoma in HIV-infected patients with hemophilia.
The combined use of Faspic and tacrolimus may increase the risk of nephrotoxic effects due to reduced PG synthesis in the kidneys.
Ibuprofen increases the hypoglycemic effect of oral hypoglycemic agents and insulin; dose adjustment may be necessary.
Cautious use in patients with liver and kidney diseases.
Long-term use of Faspik without medical advice is not recommended.
- gastric and duodenal ulcer
- bronchial asthma attacks
- high sensitivity to the drug, headache, dizziness, blood disorders.
- nausea, abdominal pain, abdominal bloating, stool disorders
- gastrointestinal bleeding
- renal failure
- disordered blood pattern
- skin rash.
Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, decreased BP, bradycardia, tachycardia, atrial fibrillation, respiratory arrest.
Treatment: gastric lavage (only within 1 hour after ingestion), prescription of activated charcoal, alkaline drinking, forced diuresis, symptomatic therapy (correction of acid-base status, BP).
It is contraindicated in children under 12 years of age.
The drug is contraindicated in pregnancy and during lactation (breast-feeding).
The use of Faspik may adversely affect female fertility and is not recommended for women planning to become pregnant.
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|Conditions of storage|
At a temperature not exceeding 40 °C
Zambon S.p.A., Italy
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