Ibuprofen, 400 mg 20 pcs

The drug belongs to the non-steroidal anti-inflammatory drugs, a derivative of phenylpropionic acid. It has analgesic, anti-inflammatory and antipyretic effects.

The effect of the agent is due to inhibition of prostaglandin synthesis by blocking the enzyme cyclooxygenase.

Inhibits platelet aggregation. With prolonged use it has a desensitizing effect.

Indications

Neuralgia, myalgia, tendinitis, bursitis, tendovaginitis, neuralgic amyotrophy, ligament sprain, hematoma, radiculitis, traumatic inflammation of soft tissue and musculoskeletal system; rheumatoid arthritis, osteoarthritis, joint syndrome in gout exacerbation, psoriatic arthritis, Bechterew’s disease (ankylosing spondylitis), cervical spondylosis, Barre-Lieu syndrome (cervical migraine, vertebral artery syndrome); symptomatic treatment of influenza and acute respiratory infections; febrile states of various genesis (including after immunization); postural hypotension when taking hypotensive drugs; nephrotic syndrome (to reduce the severity of proteinuria).

As an adjunctive agent: infectious and inflammatory diseases of the ENT-organ (tonsillitis, pharyngitis, laryngitis, sinusitis, rhinitis), bronchitis, pneumonia, pelvic inflammatory processes, adnexitis, primary dysmenorrhea, algodysmenorrhea, postoperative pain, headache and toothache, panniculitis.

Active ingredient

Composition

Ibuprofen, coated tablets:

1 tablet contains ibuprofen 400 mg;

How to take, the dosage

Ingestion, after meals.

In rheumatoid arthritis 800 mg 3 times a day is prescribed.

In osteoarthritis and ankylosing spondylitis Ibuprofen is used in 400-600 mg 3-4 times a day.

In juvenile rheumatoid arthritis the drug is used in a dose of 30-40 mg/kg body weight per day.

In case of injuries of soft tissues, sprains, the drug is prescribed in a dose of 600 mg 2-3 times a day.

In case of pain syndrome of moderate intensity the drug is prescribed in 400 mg 3 times a day. Maximal daily dose is 2.4 g.
In children over 12 years old the initial dose is 150-300 mg 3 times a day, the maximum dose is 1 g, then 100 mg 3 times a day; in juvenile rheumatoid arthritis 30-40 mg/kg/day in several doses.

For reduction of body temperature 39.2 ° C and above – 10 mg/kg/day, below 39.2 ° C – 5 mg/kg/day.

Interaction

In concomitant administration Ibuprofen may cause reduction of the diuretic effect of furosemide.

In co-administration Ibuprofen increases the effect of diphenin, coumarin anticoagulants, oral hypoglycemic agents.

Special Instructions

The drug is prescribed with caution in patients with impaired liver function, renal function, cardiovascular system diseases, with a history of peptic ulcer and/or duodenal ulcer, gastrointestinal bleeding.

In comparison with other NSAIDs, Ibuprofen has the least ulcerogenic effect on the gastrointestinal mucosa.

Long-term use of the drug requires monitoring of liver function and/or renal function, peripheral blood count.

Contraindications

Heart failure, edema, arterial hypertension, hypersensitivity, gastric or duodenal ulcer (acute stage), ulcerative colitis, optic diseases, scotoma, amblyopia, color vision disorders, liver cirrhosis with portal hypertension, “aspirin” asthma (provoked by taking ASA or other NSAIDs). NSAIDs), hemophilia, hypocoagulation, leukopenia, hemorrhagic diathesis, hearing loss, vestibular pathology, glucose-6-phosphate dehydrogenase deficiency; pregnancy (III trimester).

With caution – hyperbilirubinemia, pregnancy, lactation; peptic ulcer (in anamnesis), gastritis, enteritis, colitis; hepatic and/or renal insufficiency, blood diseases of unknown etiology, children (under 12 years).

Side effects

Nervous system disorders: headache, dizziness, decreased hearing, tinnitus, insomnia, agitation, somnolence, depression. Gastrointestinal system: nausea, vomiting, abdominal pain, heartburn, anorexia, diarrhea, flatulence, NSAID gastropathy.

Cardiac system: heart failure, tachycardia, increased blood pressure. Urinary system: edema syndrome, impaired renal function.

Allergic reactions: skin rash, pruritus, urticaria, Quincke’s edema, rare – aseptic meningitis (more common in patients with autoimmune diseases), bronchospasm.

With the organs of hematopoiesis: anemia, thrombocytopenia, agranulocytosis, leukopenia.

Overdose

Symptoms of ibuprofen overdose in children: Abdominal pain, nausea, vomiting, lethargy, headache, tinnitus, depression, drowsiness, metabolic acidosis, coma, hemorrhagic diathesis, decreased blood pressure, seizures, apnea, acute renal failure, liver dysfunction, tachycardia, bradycardia, atrial fibrillation, forced diuresis. Children under 5 years of age are especially prone to apnea, coma and seizures.

Serious effects associated with the toxic effects of the drug usually occur after taking a dose greater than 400 mg/kg body weight (i.e., 80 recommended single doses). If an overdose is suspected, seek medical attention immediately.

Treatment in case of overdose: gastric lavage, activated charcoal, alkaline drinking, symptomatic therapy.

Similarities