Indomethacin, rectal, 100 mg 6 pcs

Indomethacin has anti-inflammatory, analgesic and antipyretic, as well as some antiaggregant action.

Inhibits the activity of anti-inflammatory factors, reduces platelet aggregation. Inhibiting cyclooxygenase 1 and 2, disrupts arachidonic acid metabolism, reduces the amount of prostaglandins (Pg) both in the focus of inflammation and in healthy tissues, suppresses exudative and proliferative phases of inflammation.

When used topically it causes alleviation or disappearance of pain syndrome of rheumatic and non-rheumatic character (including In case of pain of the joints at rest and when moving, it reduces morning stiffness and swelling of the joints, increases the range of motion; in case of inflammatory processes after operations and injuries, it quickly relieves spontaneous pain as well as pain while moving, reduces inflammatory swelling of the wound area).

Indications

For systemic use: joint syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), spine pain, neuralgia, myalgia, traumatic inflammation of soft tissues and joints, rheumatism, diffuse connective tissue diseases, dysmenorrhea.

Auxiliary treatment for infectious and inflammatory diseases of the ENT organs, adnexitis, prostatitis, cystitis.

For local use: to prevent inflammation during cataract and anterior segment surgery, inhibiting miosis during surgery.

Active ingredient

Indomethacin

Composition

Active substance:

Indomethacin 100 mg

How to take, the dosage

Rectally (inserted into the rectum). Before applying the suppository it is recommended to empty the intestines.

Wash your hands, remove the suppository from the lozenge pack by cutting it with scissors or by opening it by hand, pulling the edges of the lozenge pack at different ends, and insert the suppository into the anus with the pointed end, as deeply as possible.

In order to make the suppository more comfortable to use, we recommend bending over or sitting down; you can also insert it lying on your side.

Suppositories 50 mg adults 1-3 times a day; children (over 14 years) once a day;
Suppositories 100 mg – once a day;
During a gout attack up to 200 mg a day.
It is recommended to use at night.

Interaction

Simultaneous use of indomethacin may reduce the effects of saluretics, beta-adrenoblockers; increase the effects of indirect anticoagulants.
Simultaneous use of indomethacin and diflunisal there is a risk of severe bleeding from the GI tract.
Concomitant use with probenecid may increase plasma concentration of indomethacin.
Indomethacin may decrease tubular secretion of methotrexate, which leads to increased toxicity.
Concomitant use with NSAIDs increases toxicity of cyclosporine.
Indomethacin in a dose of 50 mg 3 times / day increases the plasma concentration of lithium and reduces the clearance of lithium from the body in patients with mental illness.
Concomitant use of indomethacin with digoxin may increase the concentration of digoxin in blood plasma and increase the elimination half-life of digoxin.

Special Instructions

With caution, use in elderly patients, as well as in patients with a history of liver, renal, GI diseases, dyspeptic symptoms at the time of use, arterial hypertension, heart failure, immediately after major surgical interventions, with parkinsonism, epilepsy.

When a history of allergic reactions to NSAIDs is indicated, use only in emergency cases.

During treatment, systematic monitoring of liver and renal function, peripheral blood picture is required.
Simultaneous use with acetylsalicylic acid and other NSAIDs is not recommended.

Indomethacin should not be used concomitantly with diflunisal.

In concomitant use of indomethacin with lithium preparations, be aware of the possibility of symptoms of lithium toxicity.

When used topically, do not apply to the wounded surface of the skin, and avoid contact with the eyes or mucous membranes.

Impact on driving and operating machinery

At any time during treatment, avoid potentially hazardous activities requiring concentration and increased speed of psychomotor reactions.

Contraindications

• Individual hypersensitivity to indomethacin, aspirin or other NSAIDs (history of bronchospasm, urticaria or rhinitis caused by taking acetylsalicylic acid or other NSAIDs);
• gastric and/or intestinal ulcer in the acute phase;
• pregnancy and lactation;
• childhood (under 14 years).
• disorders of hematopoiesis;
• explicit hepatic and/or renal dysfunction;
• severe forms of chronic heart failure, arterial hypertension, pancreatitis;
• for rectal use: proctitis, recent bleeding from the rectum.

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Side effects

Digestive system disorders: nausea, anorexia, vomiting, abdominal pain and discomfort, constipation or diarrhea, erosive ulcerative lesions, bleeding and perforations of the gastrointestinal tract; rarely – intestinal strictures, stomatitis, gastritis, flatulence, bleeding from the sigmoid colon or from diverticulum, jaundice, hepatitis.

CNS and peripheral nervous system disorders:Dizziness, headache, depression, feeling of fatigue; rarely – anxiety, fainting, somnolence, seizures, peripheral neuropathy, muscle weakness, involuntary muscle movements, sleep disorders, mental disorders (depersonalization, psychotic episodes), paresthesias, dysarthria, parkinsonism.

Cardiovascular system disorders: edema, increased BP, tachycardia, chest pain, arrhythmia, palpitation, arterial hypotension, congestive heart failure, hematuria.

Allergic reactions: rare – itching, urticaria, angiitis, erythema nodosum, skin rash, exfoliative dermatitis, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, hair loss, acute respiratory distress, severe BP drop, anaphylactic reactions, angioneurotic edema, dyspnea, bronchial asthma, pulmonary edema.

Hematopoietic system: rarely – leukopenia, petechiae or ecchymoses, purpura, aplastic and hemolytic anemia, thrombocytopenia, DIC syndrome.

Senses: rarely – visual disturbances, diplopia, orbital and periorbital pain, tinnitus, hearing disorders, deafness.

Urinary system disorders: rare – proteinuria, nephrotic syndrome, interstitial nephritis, renal failure.

Metabolism disorders: rare – hyperglycemia, glucosuria, hyperkalemia.

Other: rare – vaginal bleeding, hot flashes, increased sweating, nasal bleeding, enlargement and tightness of the mammary glands, gynecomastia.

Local reactions: in place of injection in some cases – infiltrate and abscess formation; with rectal administration irritation of rectal mucosa, tenesmus, exacerbation of chronic colitis is possible.

In external application: itching, redness, rash in the application area.

Overdose

Symptoms: nausea, vomiting, severe headache, dizziness, memory impairment, disorientation. In severe cases paresthesias, numbness of extremities, convulsions.

Treatment: symptomatic therapy. Hemodialysis is ineffective.

Similarities

Indomethacin 100 Berlin-Chemie, Indomethacin 50 Berlin-Chemie, Indomethacin, Indocollir, Metindol Retard