🐾 Marfloxin solution 10%, bottle 100 ml

Marfloxin 10% solution for injection refers to antibacterial drugs of fluoroquinolones group.
The drug has a wide range of bactericidal action based on inhibition of bacterial enzymes DNA-gyrase and topoisomerase IV involved in DNA replication of microorganisms.
Marbofloxacin, the active substance of Marfloxin 10% solution for injection, is active against Gram-positive and Gram-negative microorganisms, including.including Escherichia coli, Salmonella typhimurium, Citrobacter freundii, Enterobacter cloacae, Serratia marcescens, Morganella morganii, Proteus spp, Klebsiella spp, Shigella spp, Pasteurella spp, Haemophilus spp, Moraxella spp, Pseudomonas spp, Brucella canis, Staphylococci, Streptococci and Mycoplasma spp.
After intramuscular and subcutaneous administration of the drug at a dose of 2 mg/kg marbofloxacin is well absorbed from the injection site and penetrates into most organs and tissues of the body. Bioavailability of marbofloxacin is more than 80%. Maximum concentration of marbofloxacin, about 0.5 µg/ml in piglets and 1 µg/ml in calves is reached in blood plasma after 0.5-1.5 hours. Marbofloxacin weakly binds to plasma proteins, in pigs – by 10%, in cattle – by 30%. Marbofloxacin concentration in organs is higher than in blood plasma. Half-life period of the drug in calves is 5-9 hours, in cattle with rumen digestion – 4-7 hours, in pigs 8-10 hours. When administered once in a dose of 8 mg/kg in cattle, the maximum concentration in plasma, about 3 µg/ml, is reached after about 1 hour; the elimination half-life is 15.6 hours; therapeutic concentrations are maintained for 48 hours. Marfloxacin 10% solution for injection is excreted from the body of animals mainly unchanged in the urine and feces.
Marfloxin 10% solution for injection by degree of impact on the body refers to low-hazardous substances (Hazard Class 4).

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