Xylenes, spray 0.05% 10 ml

Xylometazoline belongs to the group of local vasoconstrictors (decongestants) with alpha-adrenomimetic activity, causes narrowing of blood vessels of nasal mucosa, thus eliminating edema and hyperemia of nasal mucosa, restores nasal passageway, facilitates nasal breathing.

The drug takes effect within a few minutes after application and lasts up to 10 hours.

Pharmacokinetics

The drug is practically not absorbed when applied topically, so its concentration in the blood plasma is very low (not determined by modern analytical methods).

Indications

It is used in acute respiratory diseases with rhinitis (runny nose), acute allergic rhinitis, sinusitis, otitis media (as part of combined therapy to reduce nasopharyngeal mucosa edema), to facilitate rhinoscopy.

Active ingredient

Composition

1 ml of the spray contains:

The active ingredient:

xylometazoline hydrochloride – 0.0005 g;

Associates:

benzalkonium chloride (in terms of anhydrous),

dinatrium edetate (trilon B),

potassium dihydrophosphate,

sodium hydrophosphate dodecahydrate,

sodium chloride,

purified water.

How to take, the dosage

In children under 6 years of age (including infants) – 1-2 injections of 0.05% solution in each nasal passage 1-2 times a day for 3-5 days (no more).

Interaction

Incompatible with monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants.

Special Instructions

Should not be used for a long time, for example, in chronic rhinitis.

In colds where nasal crusts form, it is preferable to prescribe as a gel.

Contraindications

Hypersensitivity to xylometazoline and other components of the drug, arterial hypertension, tachycardia, marked atherosclerosis, glaucoma, atrophic rhinitis, brain surgery (in anamnesis), pregnancy, lactation, children under 6 years for 0.1% solution (0.001 g/ml).

With caution: coronary heart disease (angina pectoris), diabetes mellitus, prostatic hyperplasia, hyperthyroidism, children under 2 years of age – for 0.05% solution (0.0005 g/ml).

Side effects

In frequent and/or prolonged use: mucosal irritation, burning, tingling, sneezing, dry nasal mucosa, hypersecretion.

Rarely: nasal mucous membrane swelling (more often with long-term use), palpitations, heart rhythm disorders, increased blood pressure, headache, vomiting, sleep disorders, visual disturbances.

In long-term use in high doses:depression.

Overdose

Symptoms: worsening of side effects.

Treatment: symptomatic under medical supervision.

Pregnancy use

Pregnancy and lactation should be used only after careful assessment of the risk-benefit ratio for the mother and fetus, and the recommended doses should not be exceeded.

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