Slabilen, drops 7.5 mg/ml 15 ml

Pharmacotherapeutic group: laxative

ATC code: A06AB08

Pharmacological properties

Pharmacodynamics
Active ingredient – sodium picosulfate is a laxative of triarylmethane group. As local laxative sodium picosulfate after bacterial cleavage in large intestine has stimulating effect on mucosa of large intestine, increasing peristalsis, contributes to accumulation of water and electrolytes in large intestine. This leads to stimulation of the act of defecation, reduction of evacuation time and softening of stools. Sodium picosulfate, being a laxative acting at the level of the large intestine, stimulates the natural process of evacuation of contents from the lower parts of the gastrointestinal tract. Therefore, sodium picosulfate has no effect on digestion or absorption of caloric foods or essential nutrients in the small intestine.

Pharmacokinetics
Absorption and distribution
After oral administration sodium picosulfate enters the colon without significant absorption. Thus, enterohepatic circulation of the drug is excluded.
Biotransformation
Bacterial breakdown of sodium picosulfate occurs in the distal colon with the formation of the active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BGPM) with a laxative effect.
Excretion
After cleavage, a small amount of BGPM is absorbed and then almost completely bound in the intestinal wall and liver to form inactive glucuronide. After oral administration of sodium picosulfate at a dose of 10 mg (about 10.4% of the total dose), the drug is excreted in the urine as BGPM-glucuronide in 48 hours. Excretion of sodium picosulfate in higher doses decreases.
Relationship between pharmacokinetics/pharmacodynamics
The time of laxative effect development is determined by the rate of active metabolite release (HDL) and is 6-12 hours after application (on average 10 hours).

Indications

Active ingredient

Composition

How to take, the dosage

It is recommended that you start with the lowest dose possible. In order to achieve regular stools, the dose may be increased to the maximum recommended dose. The maximum recommended daily dose should not be exceeded. Because the drug is not addictive, the dose may be adjusted by the patient individually: the dose may be reduced depending on individual needs, or the drug may be used on an ad hoc basis as needed.

Age

Dosage

Maximum daily dose

Children over 10 years of age and adults

10-20 drops

(5-10 mg) per day

10 mg (20 drops)

Children 4-10 years

5-10 drops

(2.5-5 mg) per day

5 mg (10 drops)

Children 0-4 years

1 drop (0.5 mg of sodium picosulfate) per 2 kg of body weight per day

The recommended dose for children under 4 years of age is 0.25 mg/kg body weight per day.

To get a laxative effect in the morning hours, the drug should be taken the night before.

The drug does not need to be dissolved in liquid.

In order to restore the natural rhythm of defecation, besides taking the laxative preparation, it is recommended to increase physical activity, to consume enough fiber in the diet (20-25 g/day), to drink enough fluids (not less than 2 liters).

Interaction

Special Instructions

Contraindications

Side effects

Overdose

Pregnancy use

Similarities