Sulfasalazine, 500 mg 50 pcs
€9.43 €8.25
Sulfasalazine selectively accumulates in the intestinal connective tissue with the release of 5-aminosalicylic acid (5-ASA), which has anti-inflammatory activity, and sulfapyridine, which has antimicrobial bacteriostatic activity.
Indications
Ulcerative colitis (treatment of exacerbations and maintenance therapy in the remission phase);
– Crohn’s disease (mild and moderate forms in the acute phase);
– Rheumatoid arthritis; juvenile rheumatoid arthritis in ineffective non-steroidal anti-inflammatory drugs (NSAIDs).
Active ingredient
Sulfasalazine
Composition
1 tablet contains the active substance: sulfasalazine – 500.0 mg
How to take, the dosage
Orally, after meals. Ulcerative colitis, Crohn’s disease. Adults and children over 16 years of age: in 1st day – 500 mg 4 times per day; in 2nd day – 1 g 4 times per day; in 3rd and subsequent days – 1.5-2 g 4 times per day. After acute clinical symptoms of ulcerative colitis subside, a maintenance dose – 500 mg 3 – 4 times daily for several months is administered to adults and adolescents and / or body weight over 65 kg. For children from 10 to 16 years old and / or body weight from 35 to 50 kg – 500 mg 4 times a day. Maintenance therapy for children and adolescents under 16 years of age and/or with body weight less than 65 kg is not recommended. Maximal daily dose for adults is 8 g, for children under 16 years old – 2 g. Rheumatoid arthritis and juvenile rheumatoid arthritis Adults and children over 16 years of age: during the first week – 500 mg once a day, during the second week – 500 mg twice a day, the third and further – 500 mg 3 times a day. The therapeutic dose may be 1.5 to 3 g/day. Clinical effect appears after 6 to 10 weeks of therapy. The course of treatment is 6 months or more. Children from 6 to 8 years of age and/or body weight of 20-29 kg: 1 tablet 2 times a day; Children from 8 to 12 years of age and/or body weight of 30-39 kg: 1 tablet 2-3 times a day; Children from 12 to 16 years of age and/or body weight of 40-50 kg: 1 tablet 3 times a day or 2 tablets 2 times a day; Children over 16 years of age and/or body weight over 50 kg: 2 tablets 2 times a day. Maximum daily dose for children is 2 g or 40-50 mg/kg body weight.
Interaction
It enhances the effect of anticoagulants, antiepileptic and oral hypoglycemic drugs, as well as the side effects of cytostatics, immunosuppressants, hepato- and nephrotoxic drugs.
Concomitant use with sulfasalazine increases toxicity of azathioprine and mercaptopurine.
Concomitant use with ampicillin or rifampicin decreases release of 5-aminosalicylic acid from sulfasalazine molecule in the colon (due to suppression under the influence of ampicillin and rifampicin of activity of anaerobic bacteria which participate in this process). In this regard, the effectiveness of sulfasalazine may be reduced. The interaction of sulfasalazine with neomycin is believed to be similar.
In concomitant use with digoxin it may decrease its absorption; with thalinololol it may decrease absorption of thalinololol; with folic acid it may decrease absorption of folic acid.
Special Instructions
With caution use in patients with hepatic and/or renal dysfunction, patients with bronchial asthma, allergic reactions.
Augmented fluid intake is recommended during treatment.
Hypatic enzymes levels, general blood and urine tests should be monitored during treatment.
Contraindications
– Hypersensitivity to sulfasalazine or other components of the drug, as well as to sulfonamides or salicylates;
– porphyria;
– granulocytopenia; <
– aplastic anemia;
– congenital deficiency of glucose-6-phosphate dehydrogenase (risk of jaundice);
– hepatic and/or renal insufficiency;
– children under 10 years of age and/or with mass of sulfonamide or salicylic acid. – children under 10 years of age and/or body weight of 35 kg or less, with chronic inflammatory bowel disease (for this dosage form and dosage);
– bowel or urinary tract obstruction;
– children under 6 years of age with juvenile rheumatoid arthritis (effectiveness and safety not established);
– Breast-feeding period.
Side effects
Nervous system disorders: headache, dizziness, tinnitus, ataxia, seizures, sleep disorders, hallucinations, peripheral neuropathy.
Urinary system disorders: renal dysfunction, interstitial nephritis.
Digestive system disorders: nausea, vomiting, diarrhea, abdominal pain, anorexia, hepatitis, pancreatitis.
Respiratory system: interstitial pneumonitis and other pulmonary tissue lesions.
Hematopoietic system disorders: anemia, leukopenia, thrombocytopenia, agranulocytosis.
Reproductive system: transient oligospermia, infertility.
Allergic reactions: skin rash, toxic epidermal necrolysis, erythema malignant exudative, fever, anaphylactic shock.
Others: yellowing of the skin, urine, and soft contact lenses may occur.
Weight | 0.053 kg |
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Manufacturer | Ozon, Russia |
Medication form | pills |
Brand | Ozon |
Other forms…
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