Pyrogenal, rectal 100 mcg 10 pcs

Pyrogenal is an immunomodulator of wide spectrum of action, the main of which are activation of reticuloendothelial, hypothalamic-pituitary and fibrinolytic systems. Pyrogenal has adjuvant, desensitizing and anti-inflammatory properties, increases general and specific resistance of the body, influences thermoregulatory centers of hypothalamus.

The drug, by stimulating cells of the phagocytic system, activates phagocytosis, the secretion of oxygen radicals, the synthesis of interleukin-1 (IL-1, IL-2), tumor necrosis factor (TNF _L ), interferon (IFN _L ). Acting on fibroblasts, it inhibits the synthesis of collagen by fibroblasts, accelerates the process of fibrocyte maturation.

Stimulates the activity of hyaluronidase: increases tissue permeability, improves the fibrinolytic properties of blood, restores blood circulation, prevents the formation of new and resolves previously formed tight scars and adhesions, prevents vascular obliteration, stimulates tissue regeneration and epithelization.

Activates the function of the adrenal cortex: anti-inflammatory effect, increases the concentration of hormones in the blood. It stimulates the kinin system.

Indications

Pyrogenal must not be administered:

compensated forms of diseases of the cardiovascular system and diabetes are not contraindications to the use of suppositories.

Active ingredient

Composition

1 sup. contains bacterial lipopolysaccharide 100 mcg;

excipients:

cocoa butter,

lanolin,

purified water

How to take, the dosage

Rectally, 1 suppository daily or every other day, the initial dose is 50 mcg, the maximum dose is 200 mcg. The course of treatment is 12-15 suppositories.

The treatment is recommended according to the scheme: 50, 50, 50, 50, 50, 100, 100, 100, 100, 150, 150, 150, 200, 200, 200 mcg.

If the suppositories are used as monotherapy for immunorehabilitation in case of incomplete recovery after an acute bacterial or viral disease, 50 or 100 mcg suppositories should be used.

The course of treatment is 5-10 suppositories.

Simultaneous treatment with suppositories and intravenous injections is possible.

Interaction

The drug is compatible and well combined with all medications used in the treatment of the diseases and conditions mentioned in the indications.

It enhances the effectiveness of chemotherapeutic drugs in combination therapy.

Special Instructions

If within 6-8 hours hyperthermia up to 39.5°С, severe chills, headache, pain in the lower back occur, it is recommended to reduce the drug dose. When using the drug for pyrotherapy, the above described reactions are acceptable.

In the presence of seizure readiness, the drug is prescribed against a background of anticonvulsant therapy.

Contraindications

Cautions: cardiovascular disease, renal disease, diabetes, decreased seizure threshold, seizures, febrile convulsions.

Side effects

High body temperature up to 37.5 ° C), chills, malaise; rarely hyperthermia (up to 39.5 ° C), severe chills, headache, low back pain.

Pregnancy use

It is contraindicated in pregnancy and lactation.