Otrivin Menthol, spray 0.1% 10 ml

Xylometazoline has an alpha-adrenomimetic effect: it causes narrowing of the blood vessels of the nasal mucosa, eliminating edema and hyperemia of the nasopharyngeal mucosa.< br> < br> Xylometazoline also reduces the accompanying mucus hypersecretion and facilitates the drainage of nasal passages blocked with nasal discharge and thus improves nasal breathing in cases of nasal congestion. Otrivin® has a balanced pH value, typical for the nasal cavity. < br> < br> Menthol and eucalyptol contained in the product have a cooling effect on the nasal mucous membrane, giving a feeling of freshness. < br> < br> In therapeutic concentrations the drug does not irritate the mucous membranes and does not cause flushing.< br> < br> The action comes within 2 minutes after application and lasts for 12 h.< br> < br> Studies in vitro have shown that in humans xylometazoline suppresses the infectious activity of rhinovirus that causes the “cold”.

Indications

Otitis, Allergies, Runny nose (rhinitis), Sinusitis, Colds, Pollinosis, Nasal congestion, Flu, Allergic rhinitis, Sneezing

• acute respiratory diseases with rhinitis (runny nose) phenomena;

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• acute allergic rhinitis, pollinosis, sinusitis, eustachitis, otitis media (to reduce nasopharyngeal mucosa edema);
• preparing the patient for diagnostic manipulations in the nasal passages.

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Active ingredient

Xylometazoline

Composition

1 ml contains:

The active ingredient:

Xylometazoline hydrochloride 1 mg.

Auxiliary substances:

• Sodium dihydrophosphate dihydrate;
• Sodium hydrophosphate dodecahydrate;
• Sodium chloride;
• Benzalkonium chloride (in the form of 50% solution);
Sorbitol 70%;
• Dinatrium edetate;
• Levomenthol (menthol);
• Levomenthol (menthol);
• Macrogol glyceryl hydroxystearate;
• Purified water.

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How to take, the dosage

Intranasal.

Adults and children over 12 years of age: 1 injection into each nasal passage 3 times/day.

Do not use more than 3 times/day.

It is recommended to use last time just before going to bed.

Interaction

Incompatible with MAO inhibitors and tricyclic antidepressants.

Special Instructions

It is not recommended to use continuously for more than 10 days.

Do not exceed the recommended doses, especially in children and elderly patients.

Long (more than 10 days) or excessive use of the drug may cause the effect of “ricochet” (rhinitis medica) and/or atrophy of the nasal mucosa.

Impact on the ability to drive and operate machinery

Xylometazoline does not affect the ability to drive vehicles and operate mechanisms.

Synopsis

Dosed nasal spray (with menthol and eucalyptus) 0.1% as a colorless opalescent solution with a distinctive smell of menthol and eucalyptus.

Contraindications

• Hypersensitivity;
• arterial hypertension;
• tachycardia;
• expressed atherosclerosis;
• closed-angle glaucoma;
• atrophic rhinitis;
• hyperthyroidism;
• cerebral surgery (history);
• children under 6 years of age.

With caution, use in patients with diabetes mellitus, cardiovascular disease, hypersensitivity to adrenergic drugs, accompanied by symptoms of insomnia, dizziness, cardiac arrhythmia, tremor, high blood pressure.

Side effects

Determination of the frequency of adverse reactions: very common ≥10); common (≥1/100, < 1/10); infrequent (≥1/1000, < 1/100); rare (≥1/10 000, < 1/1000); very rare (< 1/10 000).

Immune system disorders: very rare – hypersensitivity reactions (angioedema, rash, itching).

Nervous system: often – headache, rarely – insomnia, depression (with prolonged use in high doses).

Senses: very rarely – visual perception disorders.

Cardio-vascular system: rare – palpitation, increased BP, very rare – tachycardia, arrhythmia.

Respiratory system: frequent – irritation and / or dryness of the nasopharyngeal mucosa, burning, tingling, sneezing, hypersecretion of nasophary mucosa.

The digestive system: often – nausea, rarely – vomiting.

Local reactions: often – burning at the application site.

If any of the above side effects worsen, or the patient noticed any other side effects, he should inform the doctor.

Overdose

Symptoms: xylomethasoline may cause severe dizziness, increased sweating, rapid decrease in body temperature, headache, bradycardia, increased blood pressure, respiratory depression, coma and seizures if applied topically in excessive doses or if ingested accidentally. A sharp decrease in BP may follow the increase.

Treatment: appropriate supportive measures should be taken if overdose is suspected, and in some cases immediate symptomatic treatment under medical supervision is indicated. These measures should include observation of the patient for several hours. In case of severe poisoning with cardiac arrest, resuscitation measures should continue for at least 1 hour.

Pregnancy use

The drug should not be used during pregnancy.

During lactation, use only under medical supervision and after careful assessment of the risk-benefit ratio for the mother and fetus.

It is not allowed to exceed the recommended dose.

Similarities

Atrivin, Galazolin, Xylen, Snoop, Rinonorm, Xymelin Eco, Rinorus, Rinostop, Rinomaris, Xylometazolin, Tisin Classic, Xymelin Eco Menthol, Asterisk, Xyloct, Cold and Flu, Asterisk for Colds, Quatran xylo