Otrivin Moisturizing Formula, spray 0.1% 10 ml

Xylometazoline has an alpha-adrenomimetic effect: it causes narrowing of nasal mucosal blood vessels, eliminating edema and hyperemia of nasopharyngeal mucosa. Xylometazoline also reduces the accompanying hypersecretion of mucus and facilitates the drainage of nasal passages blocked by secretions, thereby improving nasal breathing in cases of stuffy noses.< br> < br> Otrivin® is well tolerated by patients with sensitive mucous membranes and its effects do not interfere with the separation of mucus. Otrivin® has a balanced pH value, typical for the nasal cavity. < br> < br> Menthol and eucalyptol contained in the product have a cooling effect on the nasal mucosa, resulting in a feeling of freshness. < br> In therapeutic concentrations the drug does not irritate the mucosa, does not cause hyperemia.< br> < br> The action comes within 2 minutes after application and lasts for 12 h.< br> < br> In vitro studies have shown that in humans xylometazoline suppresses the infectious activity of rhinovirus that causes “colds”.< br>

Indications

Sinusitis, Flu, Gymorrhoea, Pollinosis, Allergies, Runny nose (rhinitis), Colds, Allergic rhinitis, Nasal congestion, Otitis

• Acute respiratory diseases with rhinitis (runny nose) phenomena;
acute allergic rhinitis, pollinosis, sinusitis, eustachitis, otitis media (to reduce nasopharyngeal mucosa edema);
• preparing the patient for diagnostic manipulations in the nasal passages.

.

Active ingredient

Xylometazoline

Composition

1 ml contains:

Active substance:

Xylometazoline hydrochloride 1 mg.

Auxiliary substances:

Sodium dihydrophosphate dihydrate;
Sodium hydrophosphate dodecahydrate;
Sodium chloride;
Benzalkonium chloride (in the form of 50% solution);
Sorbitol 70%;
Dinatrium edetate;
Levomenthol (menthol);
Cineol (eucalyptol);
Macrogol glycerylhydroxystearate;
Purified water.

How to take, the dosage

Intranasally.

Adults and children over 12 years of age – 1 injection in each nasal passage 3 times a day.

Do not use more than 3 times a day.

Interaction

Xylometazoline is contraindicated in patients currently receiving MAO inhibitors or who received them during the previous 2 weeks.

Simultaneous use of tri- or tetracyclic antidepressants and sympathomimetic drugs may increase the sympathomimetic effect of xylometazoline, so this combination should be avoided.

Special Instructions

It is not recommended to use continuously for more than 10 days.

The recommended doses should not be exceeded, especially in children and the elderly.

Prolonged (more than 10 days) or excessive use of the drug may cause a ricochet effect (medicated rhinitis).

Synopsis

Dosed nasal spray 0.1% as a clear colorless solution, almost odorless.

Contraindications

• High sensitivity to the ingredients of the drug;
• arterial hypertension;
• tachycardia;
• explicit atherosclerosis;
• glaucoma;

hyperthyroidism;

surgical interventions.glaucoma;

• atrophic rhinitis;
• hyperthyroidism;
• cerebral surgery (history);
• children under 6 years of age.

With caution, use in patients with diabetes mellitus, cardiovascular disease, hypersensitivity to adrenergic drugs, accompanied by symptoms of insomnia, dizziness, cardiac arrhythmia, tremor, high blood pressure.

Side effects

Determination of the frequency of adverse reactions: very common ≥10); common (≥1/100, < 1/10); infrequent (≥1/1000, < 1/100); rare (≥1/10 000, < 1/1000); very rare (< 1/10 000).

Immune system disorders: very rare – hypersensitivity reactions (angioedema, rash, itching).

Nervous system: often – headache, rarely – insomnia, depression (with prolonged use in high doses).

Senses: very rarely – visual perception disorders.

Cardio-vascular system: rare – palpitation, increased BP, very rare – tachycardia, arrhythmia.

Respiratory system: frequent – irritation and / or dryness of the nasopharyngeal mucosa, burning, tingling, sneezing, hypersecretion of nasophary mucosa.

The digestive system: often – nausea, rarely – vomiting.

Local reactions: often – burning at the application site.

If any of the above side effects worsen, or the patient noticed any other side effects, he should inform the doctor.

Overdose

Symptoms: xylomethasoline may cause severe dizziness, increased sweating, rapid decrease in body temperature, headache, bradycardia, increased blood pressure, respiratory depression, coma and seizures if applied topically in excessive doses or if ingested accidentally. A sharp decrease in BP may follow the increase.

Treatment: appropriate supportive measures should be taken if overdose is suspected, and in some cases immediate symptomatic treatment under medical supervision is indicated. These measures should include observation of the patient for several hours. In case of severe poisoning with cardiac arrest, resuscitation measures should continue for at least 1 hour.

Pregnancy use

The drug should not be used during pregnancy.

During lactation, use only under medical supervision and after careful assessment of the risk-benefit ratio for the mother and fetus.

It is not allowed to exceed the recommended dose.

Similarities

Atrivin, Galazolin, Xylen, Snoop, Rinonorm, Xymelin Eco, Rinorus, Rinostop, Rinomaris, Xylometazolin, Tisin Classic, Xymelin Eco Menthol, Asterisk, Xyloct, Cold and Flu, Asterisk for Colds, Quatran xylo