Nasivin, spray 0.05% 10 ml

Nasivin is an alpha-adrenomimetic, vasoconstrictor.

As an imidazoline derivative, at low concentrations it has mainly α2-adrenomimetic effect, at high concentrations it also acts on α1-adrenoreceptors.

It narrows blood vessels at the application site, reduces swelling of the nasal mucosa and the upper respiratory tract. When applied locally nasally in therapeutic concentrations it does not irritate the mucosa and does not cause hyperemia.

Studies of radioactive isotope-labeled oxymetazoline have shown that this rhinological agent administered through the nose has no systemic action.

Indications

Acute respiratory diseases with symptoms of rhinitis;
Acute allergic rhinitis;
Exacerbation of vasomotor rhinitis;
To facilitate the outflow of discharge from the paranasal sinuses in case of sinusitis, eustachitis, otitis media;
To eliminate swelling before diagnostic manipulations in the nasal passages.

Pharmacological effect

Nazivin is an alpha-adrenomimetic, vasoconstrictor.

Being an imidazoline derivative, at low concentrations it mainly has an α2-adrenomimetic effect, and at high concentrations it also acts on α1-adrenergic receptors.

Constricts blood vessels at the site of application, reduces swelling of the nasal mucosa and upper respiratory tract. When applied locally at therapeutic concentrations, it does not irritate the mucous membrane and does not cause hyperemia.

Studies of radiolabeled oxymetazoline have shown that this rhinological agent, administered through the nose, has no systemic effect.

Special instructions

Long-term use of decongestants for nasal instillation may lead to a weakening of their effect.

Abuse of these drugs can cause mucosal atrophy and reactive hyperemia with rhinitis medicamentosa, as well as damage to the mucosal epithelium and inhibition of epithelial activity.

Long-term use and overdose should be avoided.

Active ingredient

Oxymetazoline

Composition

1 ml contains:

oxymetazoline hydrochloride 0.5 mg.

Contraindications

Hypersensitivity;

Atrophic rhinitis;

Angle-closure glaucoma.

Age up to 1 year – for Nazivin® 0.025 and 0.05%;

Ages up to 6 years – for Nazivin® 0.05%.

Side Effects

Sometimes – burning or dryness of the nasal mucosa, sneezing;

Rarely – a strong feeling of nasal congestion (reactive hyperemia);

Very rarely – anxiety, insomnia, fatigue, headache, nausea.

Repeated overdose with local nasal use sometimes leads to such systemic sympathomimetic effects as increased heart rate (tachycardia) and increased blood pressure.

Overdose

Symptoms (after significant overdose or accidental ingestion):

constriction of the pupils, nausea, vomiting, cyanosis, increased body temperature, tachycardia, arrhythmia, vascular insufficiency, arterial hypertension, respiratory disorders, pulmonary edema, cardiac arrest; in addition, mental disorders may appear, as well as depression of central nervous system functions, accompanied by drowsiness, decreased body temperature, bradycardia, arterial hypotension, respiratory arrest and possible development of coma.

Treatment:

gastric lavage, taking activated carbon and urgently contacting a doctor.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 °C.

Shelf life

3 years.

Manufacturer

Russia