Mycoderil, cream 1% 15 g
€13.88 €12.14
Mycoderil is an antifungal agent intended for external use, belonging to the class of allilamines. Their active ingredient is naphthifin.
The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to reduction of formation of ergosterol which is a part of the cell wall of the fungus. Naftifine, affecting squalene epoxidase, does not affect the cytochrome P-450 system.
Naftifine is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, yeast and yeast-like fungi (Candida spp., Pityrosporum), molds (Aspergillus) and other fungi (such as Sporothrix schenckii). Against dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi the drug shows fungicidal or fungistatic activity depending on the strain of the microorganism.
Naftifine has antibacterial activity against Gram-positive and Gram-negative microorganisms causing secondary bacterial infections.
Naftifine has anti-inflammatory properties that help to quickly disappear the symptoms of inflammation, especially itching.
Pharmacokinetics
When applied externally, it penetrates well into various layers of the skin, creating sustained antifungal concentrations in various skin layers. After application on the skin less than 6% of naphthifin is absorbed systemically. The absorbed amount is partially metabolized and excreted by the kidneys and through the intestine. T1/2 of the drug is 2-3 days.
Indications
Active ingredient
Composition
1 g of the cream: the active ingredient:
naphthyphine hydrochloride – 10 mg;
additional components:
isopropyl myristate – 80 mg,
cetostearyl alcohol – 80 mg,
How to take, the dosage
Externally.
In case of skin lesions Mikoderil is applied once a day on the affected skin surface and adjacent areas after thorough cleaning and drying (taking approximately 1 cm of healthy skin area at the edges of the affected area).
The therapy duration in case of dermatomycosis is 2-4 weeks (up to 8 weeks if needed), with candidiasis – 4 weeks.
In case of nail lesions Mikoderil is applied 2 times a day on the affected nail.
Before the first use of the drug, remove the affected part of the nail with scissors or a nail file as much as possible. The duration of therapy for onychomycosis is up to 6 months.
To prevent relapse, treatment should be continued for at least 2 weeks after the disappearance of clinical symptoms.
Special Instructions
A course of treatment is required.
Mycoderil is not indicated for use in ophthalmology.
Contact with the drug in the eyes and on open wounds should be avoided.
Pediatric use: caution should be exercised when using in children under 18 years of age (the drug has not been proven to be effective or safe).
Contraindications
Side effects
In some cases, local reactions may occur: dry skin, skin hyperemia and burning.
The side effects are reversible and do not require treatment withdrawal.
If any of the side effects listed in the instructions worsen, or if any other side effects not listed in the instructions are noted, you should tell your doctor immediately.
Pregnancy use
Similarities
Weight | 0.025 kg |
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Conditions of storage | At a temperature not exceeding 25 °C. |
Manufacturer | Lekko ZAO, Russia |
Medication form | exterior cream |
Brand | Lekko ZAO |
Other forms…
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