Mycoderil, cream 1% 30 g
€21.93 €18.27
Pharmacodynamics
Naftifin is an antifungal agent for external use, belonging to the class of allilamines. The mechanism of action is related to inhibition of squalene-2,3-epoxidase, which leads to reduction of formation of ergosterol, which is a part of the cell wall of the fungus. It is active against dermatophytes such as Trichophyton, Epidermophyton and Microsporum, molds (Aspergillus spp.), yeasts (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii).
With respect to dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi the drug has fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against Gram-positive and Gram-negative microorganisms that can cause secondary bacterial infections. It has anti-inflammatory action, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.
Pharmacokinetics
When applied topically, it penetrates well into various layers of the skin, creating stable antifungal concentrations in its various layers. After application on the skin less than 6% of naphthifin is absorbed systemically. Absorbed amount is partially metabolized and excreted by kidneys and intestine. Half-life period of the drug is 2 – 3 days.
Indications
Skin itch, Fungus, Nail fungus, Skin fungus
– Fungal infections of smooth skin and skin folds (tinea corporis, tinea inquinalis);
– interfinger mycoses (tinea manum, tinea pedum);
– fungal infections of the nails (onychomycoses);
– candidiasis of the skin;
– peptic ulcer;
– dermatomycoses (with or without itching).
Active ingredient
Naftifin
Composition
1 g of the cream: the active ingredient:
naphthyphine hydrochloride – 10 mg;
additional components:
isopropyl myristate – 80 mg,
cetostearyl alcohol – 80 mg, <
Polysorbate 60 – 61 mg,
Cetylpalmitate – 20 mg,
sorbitan stearate – 19 mg,
benzyl alcohol – 10 mg,
sodium hydroxide – 1.2 mg,
purified water – up to 1000 mg.
How to take, the dosage
Externally.
In case of skin lesions Mikoderil is applied 1 time/day on the affected skin surface and adjacent areas after thorough cleaning and drying (covering about 1 cm of healthy skin area at the edges of the affected area).
The duration of therapy in dermatomycosis is 2-4 weeks (up to 8 weeks if necessary), in candidiasis – 4 weeks.
In case of nail lesions Mikoderil is applied 2 times a day on the affected nail. Before the first use, remove the affected part of the nail with scissors or a nail file as much as possible.
The duration of therapy for opichomycosis is up to 6 months.
To prevent a relapse, treatment should be continued for at least 2 weeks after clinical symptoms have disappeared.
Interaction
Interaction of Mycoderil with other drugs was not noted.
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Special Instructions
According to the instructions, Mikoderil is not intended for use in ophthalmology.
Contraindications
– Hypersensitivity to naphthyphine, benzyl alcohol or other components of the drug;
– pregnancy and lactation (safety and effectiveness of the drug in this category of patients has not been studied).
With caution: childhood (clinical experience is limited).
Side effects
There may be reactions at the site of application: dry skin, skin hyperemia and burning.
Pregnancy use
The safety profile of naphthifin when used during pregnancy and lactation has not been studied, so Mikoderil is contraindicated for women during these periods of life.
Similarities
Exoderil, Mycoderil, Mizol, Naftoderil, Naftifin, Fungoderil
Weight | 0.047 kg |
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Shelf life | 2 years if the manufacturer's recommendation is followed |
Conditions of storage | Storage temperature not more than 25 ° C.. |
Manufacturer | Lekko ZAO, Russia |
Medication form | exterior cream |
Brand | Lekko ZAO |
Other forms…
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