Mycoderil, 1% 20 ml

Mycoderil^® is an antifungal drug for external use, the active ingredient of which is naphthifine. Naphtifine is an antifungal agent belonging to the class of alilamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. Naftifine, affecting squalene epoxidase, does not affect the cytochrome P-450 system.

Naftifine is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, yeast and yeast-like fungi (Candidaspp., Pityrosporum), molds (Aspergillus) and other fungi (such as Srohichryshepensis). Against dermatophytes and aspergillus naphthifin acts fungicidal.

In yeast fungi the drug has fungicidal or fungistatic activity depending on the strain of the microorganism. Naphtifine has antibacterial activity against Gram-positive and Gram-negative microorganisms causing secondary bacterial infections.

Naftifine has anti-inflammatory properties that help to quickly disappear the symptoms of inflammation, especially itching.

Pharmacokinetics

When used topically, naphthifin quickly penetrates the skin, creating sustained antifungal concentrations in different layers of the skin, making once-daily use possible.

Indications

.

Active ingredient

Naftifin

Composition

Active ingredient:
naphthyphine hydrochloride – 10.0 mg.
Excipients:
propylene glycol – 50.0 mg,
ethanol (ethyl alcohol 95%) – 400.0 mg,
purified water – up to 1 ml.

How to take, the dosage

Outwardly.

In dermatomycoses and candidiasis

Micoderil®, spray for external use, 1% is applied once a day to the affected skin surface and its neighbors after thorough cleaning and drying, covering approximately 1 cm of healthy skin area at the edges of the affected area. Duration of treatment: 2-4 weeks in dermatomycosis (if necessary – up to 8 weeks), 4 weeks in candidiasis.

In case of nail diseases (onychomycosis)

Before the first use of the preparation the affected part of the nail is removed with scissors and a nail file. The drug is used twice a day, the duration of treatment for onychomycosis is up to 6 months. It is recommended to continue using the drug for at least 2 weeks after the clinical symptoms disappear in order to prevent the recurrence of the infection.

If after the treatment the improvement is not observed or the symptoms worsen, or new symptoms appear, it is necessary to consult a physician. Use the drug only according to the indications, the method of administration and in the doses specified in the instructions for use.

Interaction

Interaction with other drugs has not been studied.

Special Instructions

Please read the instructions for use carefully before using this medicine because they contain important information for you.

• Keep the instructions carefully, you may need them again.
• The medicine you are taking is for you, not for others, because it can cause them harm, even if you have the same symptoms as you do.

Mycoderil®, a spray for external use, 1% is effective in treating mycoses affecting areas of skin with hyperkeratosis and in areas of hair growth.
A course of treatment is required.
Avoid contact of the drug with eyes and open wounds.
Pediatric use
The drug should be used with caution in children.

Mycoderil®, topical spray, 1% has no adverse effect on the ability to drive vehicles and perform other activities requiring concentration and quick psychomotor reactions.

Contraindications

Hypersensitivity to naphthyphine or propylene glycol; pregnancy and breastfeeding (safety and effectiveness of the drug in this category of patients has not been studied).
Application of the drug on the wound surface is contraindicated.