Mycoderil, 1% 10 ml

Mycoderil^® is an antifungal drug for external use, the active ingredient of which is naphthifine. Naphtifine is an antifungal agent belonging to the class of alilamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. Naftifine, affecting squalene epoxidase, does not affect the cytochrome P-450 system.

Naftifine is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, yeast and yeast-like fungi (Candidaspp., Pityrosporum), molds (Aspergillus) and other fungi (such as Srohichryshepensis). Against dermatophytes and aspergillus naphthifin acts fungicidal.

In yeast fungi the drug has fungicidal or fungistatic activity depending on the strain of the microorganism. Naphtifine has antibacterial activity against Gram-positive and Gram-negative microorganisms causing secondary bacterial infections.

Naftifin has anti-inflammatory properties that help to quickly disappear the symptoms of inflammation, especially itching.

Pharmacokinetics

When applied topically, naphthifin quickly penetrates the skin, creating sustained antifungal concentrations in its various layers, making once-daily use possible.

Indications

Active ingredient

Composition

How to take, the dosage

Externally.

In dermatomycosis and candidiasis of the skin

Mycoderil, solution for external use, 1% is applied once a day to the affected skin surface and its neighboring areas after thorough cleaning and drying, covering about 1 cm of healthy skin area at the edges of the affected area.

The course of treatment: with dermatomycosis 2-4 weeks (up to 8 weeks if necessary), with candidiasis – 4 weeks.

In case of nail lesions (onychomycosis)

Before the first use of the drug, remove the affected part of the nail with scissors and a nail file as much as possible. The drug is used 2 times a day, the duration of treatment for onychomycosis is up to 6 months.

In order to prevent recurrence of infection the drug should be continued for at least 2 weeks after the disappearance of clinical symptoms.

Interaction

The interaction with other drugs has not been studied.

Special Instructions

Mycoderil, a solution for external use, 1% is effective in the treatment of mycoses affecting areas of the skin with hyperkeratosis, as well as in areas of hair growth.

Course treatment is required.

Contact of the drug in the eyes and on open wounds should be avoided.

Pediatric use

The drug should be used with caution in children.

Impact on ability to drive vehicles and other activities requiring increased concentration

Mycoderil, topical solution, 1% has no adverse effect on the ability to drive vehicles and perform other activities requiring concentration and quick psychomotor reactions.

Contraindications

Cautions: Children (clinical experience is limited).

Side effects

In some cases there may be local reactions: dry skin, skin hyperemia and burning.

The side effects are reversible and do not require treatment withdrawal.

If any of the side effects listed in the instructions worsen, or if any other side effects not listed in the instructions are noted, you should tell your doctor immediately.

Overdose

No cases of overdose have been reported.

Pregnancy use

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