Mizol gel tube, 30 g
€17.05 €14.21
Naphtifine is an antifungal agent for external use belonging to the class of allilamines. The mechanism of action is associated with inhibition of squalene-23-epoxidase, which leads to a decrease in the formation of ergosterol which is part of the cell wall of the fungus. It is active against dermatophytes such as Trichophyton epidermophyton and microsporum molds (Aspergillus spp.) yeast fungi (Candida spp. Pityrosporum) and other fungi (such as Sporothrix schenckii).
Against dermatophytes and aspergillus naphthifin acts fungicide. Against yeast fungi the drug has fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against Gram-positive and Gram-negative microorganisms that can cause secondary bacterial infections. It has anti-inflammatory activity that causes rapid disappearance of inflammatory symptoms, especially itching.
Pharmacokinetics:
When applied topically naphthifin quickly penetrates into the skin creating stable antifungal concentrations in its various layers making it possible to use once a day.
Pharmacological effect
Naftifine is an antifungal agent for external use belonging to the class of allylamines. The mechanism of action is associated with inhibition of squalene-23-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. Active against dermatophytes such as trichophyton epidermophyton and microsporum molds (Aspergillus spp.), yeast fungi (Candida spp.. Pityrosporum) and other fungi (for example Sporothrix schenckii).
Naftifine has a fungicidal effect against dermatophytes and aspergillus. Against yeast fungi, the drug exhibits fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against gram-positive and gram-negative microorganisms that can cause secondary bacterial infections. It has an anti-inflammatory effect which contributes to the rapid disappearance of symptoms of inflammation, especially itching.
Pharmacokinetics:
When used externally, naftifine quickly penetrates the skin, creating stable antifungal concentrations in its various layers, which makes it possible to use it once a day.
Active components
Naftifine is an antifungal drug from the allylamine group, has an anti-inflammatory effect, promotes the rapid disappearance of symptoms of inflammation, especially itching.
Tea tree oil has pronounced antiseptic and antibacterial properties. Due to the presence of a rare ingredient – viridoflorene (even bactericidal plants such as eucalyptus and rosemary do not have it), the antiseptic effect of tea tree oil is 12 times higher than that of phenol, and 8 times higher than that of carboxylic acid.
In addition, it eliminates the side effects of naftifine, such as dryness, redness, etc.
Ethyl alcohol is a solvent and antiseptic, a preservative, drying and cooling additive that ensures the transport of active compounds into the skin, accelerates the drying of the gel on the surface of the skin or nail plate with the formation of a non-sticky film.
Composition
1 ml of solution contains
Active ingredient: naftifine hydrochloride – 10.00 mg
Excipients: propylene glycol – 50.00 mg; ethanol (ethyl alcohol) 95% – 400.00 mg; purified water – 475.00 mg.
Pregnancy
The use of Mizol® Evalar during pregnancy and breastfeeding is contraindicated (the safety and effectiveness of naftifine in this category of patients has not been studied).
Contraindications
Hypersensitivity to naftifine or propylene glycol.
Pregnancy and breastfeeding (safety and effectiveness have not been established).
Application of the drug to the wound surface is contraindicated.
With caution:
Children’s age (experience of clinical use is limited).
Recommendations for use
The gel is applied to clean, dry nails and the skin around them (damaged areas) in a thin layer over the entire surface of the nail once a day, after application, dry the nail for 1-2 minutes.
Duration of use is from 2 to 8 weeks. If hypersensitivity or an allergic reaction occurs, stop using the gel. Avoid contact with mucous membranes of the eyes and mouth.
Shelf life
2 years.
Manufacturer
Evalar CJSC, Russia
Shelf life | 2 years. |
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Manufacturer | Evalar, Russia |
Medication form | gel for external use |
Brand | Evalar |
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