Mizol Evalar, 1% 50 ml

Pharmacological group: antifungal agent

ATX code: D01AE22

Pharmacological properties

Pharmacodynamics

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Naftifin is an antifungal agent for external use, belonging to the class of allilamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. It is active against dermatophytes such as Trichophyton, Epidermophyton and Microsporum, molds (Aspergillus spp.), yeasts (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii). Against dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi the drug exhibits fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against Gram-positive and Gram-negative microorganisms that can cause secondary bacterial infections. It has anti-inflammatory action, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.

Pharmacokinetics

When applied externally, naphthifin quickly penetrates the skin, creating sustained antifungal concentrations in its various layers, making once-daily use possible.

Indications

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Active ingredient

Naftifin

Composition

1 ml of the solution contains:

The active ingredient: naphthyphine hydrochloride – 10.00 mg

Supplementary substances: propylene glycol – 50.00 mg; ethanol (ethyl alcohol) 95% – 400.00 mg; purified water – 475.00 mg.

How to take, the dosage

Externally.

Misol^® Evalar is applied once a day to the affected skin surface and its neighboring areas (about 1 cm of healthy skin at the edges of the affected area) after thoroughly cleaning and drying them. Duration of therapy in dermatomycosis – 2-4 weeks (if necessary – up to 8 weeks), in candidiasis – 4 weeks.

When the nails are affected, Mizol ^® Evalar is applied 2 times a day to the affected nail. Before the first use of the drug, remove the affected part of the nail with scissors or a nail file as much as possible. The duration of therapy for onychomycosis is up to 6 months.

To prevent relapse, treatment should be continued for at least 2 weeks after clinical symptoms have disappeared.

If there is no improvement after treatment or if new symptoms develop, consult a physician. Use the drug only according to the route of administration and in the dosage indicated in the instructions. If necessary, please talk to your doctor before using the medicine.

Interaction

Interaction with other drugs has not been studied.

Special Instructions

The drug Mizol® Evalar is not intended for use in ophthalmology. The drug should not be allowed to get into the eyes.
A course of treatment is required to achieve therapeutic effect.
Misol® Evalar is effective for treatment of mycosis affecting the skin areas with hyperkeratosis as well as hair growth areas.
Propylene glycol, which is part of the solution, may cause skin irritation; in case of side effects it is necessary to stop using the drug and consult a physician.
Influence on ability to drive vehicles and mechanisms
Mizol® Evalar has no effect on performance of potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Synopsis

Transparent colorless or nearly colorless solution with the odor of ethanol.

Contraindications

Hypersensitivity to naphthyphine or propylene glycol.

Pregnancy and breastfeeding (safety and efficacy of use have not been established).

Application on the wound surface is contraindicated.

Cautions

Childhood (clinical experience limited).

Side effects

In some cases there may be local reactions: dry skin, skin hyperemia and burning. Side effects are reversible and do not require discontinuation of treatment.

If you have any of the side effects mentioned in the instructions, or if they get worse, or if you notice any other side effects not mentioned in the instructions, tell your doctor.

Overdose

When using the drug in accordance with the instructions for use, overdose is unlikely. In case of accidental ingestion gastric lavage and symptomatic therapy are indicated.

Pregnancy use

The use of the drug Mizol® Evalar during pregnancy and during breastfeeding is contraindicated (safety and efficacy of naphthifin in this category of patients has not been studied).

Similarities

Exoderil, Mycoderil, Mizol, Naftoderil, Naftifin, Fungoderil