Ibuprofen, 100 mg/5 ml suspension 100 ml

Ibuprofen is a nonsteroidal anti-inflammatory drug, a derivative of phenylpropionic acid.

It has anti-inflammatory, analgesic and antipyretic effects.

The drug effect is due to inhibition of prostaglandin synthesis by blocking the enzyme cyclooxygenase.

Inhibits platelet aggregation. With prolonged use it has a desensitizing effect.

Indications

Ibuprofen for children is used from 3 months to 12 years for symptomatic treatment as antipyretic in acute respiratory diseases, influenza, childhood infections, other infectious and inflammatory diseases and post-vaccination reactions and accompanied by fever.

. The drug is used as a symptomatic analgesic for pain syndrome of mild to moderate intensity, including headache, toothache, migraine, neuralgia, pain in the ears and throat, sore throat, pain from sprains, muscle pain, rheumatic pain, joint pain The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, has no effect on disease progression.

Active ingredient

How to take, the dosage

Ibuprofen oral suspension is specially formulated for children. It is administered orally. Patients with hypersensitivity of the stomach are recommended to take the drug with food.

For short-term use only. Read the instructions carefully before taking this medicine.

Shake well until a smooth suspension is formed before use. A syringe, measuring spoon or measuring cup is included for exact measuring of the product.

5 ml. of the product contains 100 mg. Ibuprofen or 1 ml. contains 20 mg. Ibuprofen.

Fever (fever) and pain:

The dosage for children depends on the child’s age and body weight. The maximum daily dose should not exceed 30 mg/kg of body weight of the child with 6-8 hours between doses.

Interaction

In concomitant administration Ibuprofen may cause reduction of the diuretic effect of furosemide.

In co-administration Ibuprofen increases the effect of diphenin, coumarin anticoagulants, oral hypoglycemic agents.

Special Instructions

In long-term use, nonsteroidal anti-inflammatory drugs may cause gastric mucosal damage, peptic ulcers and bleeding from the digestive tract. During long-term treatment with NSAIDs, monitoring of peripheral blood count and liver and kidney function is necessary. If gastropathy symptoms occur, close monitoring is indicated, including esophagogastroduodenoscopy, blood tests with determination of Hb, hematocrit, stool analysis for occult blood.

Interaction with other medicinal products ibuprofen should not be used concomitantly with other nonsteroidal anti-inflammatory drugs (for example, acetylsalicylic acid reduces the anti-inflammatory effect of ibuprofen and increases the side effect). Simultaneous prescription of ibuprofen and diuretics should be avoided, if possible, because of, on the one hand, weakening of diuretic effect and, on the other hand, the risk of renal failure. Ibuprofen weakens the effect of hypotensive drugs (angiotensin conversion inhibitors, -adrenergic agents, thiazides).

Inhibits the hypotensive effect of ACE inhibitors, while reducing their excretion by the kidneys. Ibuprofen increases the effect of oral hypoglycemic agents (especially sulfonylurea derivatives) and insulin. Microsomal oxidation inducers phenytoin, ethanol, barbiturates, zixorin, rifampicin, phenylbutazone, tricyclics (antidepressants) increase production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions. Microsomal oxidation inhibitors – reduce the risk of hepatotoxic effects.

It enhances the effect of indirect anticoagulants, antiaggregants, fibrinolytics (increased risk of hemorrhagic complications). Increases the blood concentration of digoxin. Increases the toxic effects of methotrexate and lithium drugs. Caffeine increases the analgesic effect.

Contraindications

Hypersensitivity, gastrointestinal (GI) erosive and ulcerative diseases in the acute stage (including gastric and duodenal ulcer, ulcerative colitis, Crohn’s disease), full or partial combination of bronchial asthma, recurrent polyposis of the nose and sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including history), clotting disorders (including hemophilia, prolonged bleeding time, susceptibility to bleeding, hemorrhagic diathesis), active gastrointestinal bleeding; severe renal insufficiency (creatinine clearance less than 30 ml/min), advanced renal disease, severe hepatic insufficiency or active liver disease, conditions after coronary artery bypass grafting, confirmed hyperkalemia, inflammatory bowel disease, hereditary fructose intolerance due to the presence of sorbitol in the drug.

WARNING

Take in patients with – cirrhosis with portal hypertension; hepatic and/or renal insufficiency, heart failure, nephrotic syndrome, hyperbilirubinemia, peptic ulcer (in anamnesis), gastritis, enteritis, colitis, blood diseases of unknown etiology (leukopenia and anemia), pregnancy (II-III trimester), lactation. If it is necessary to determine 17-ketosteroids the drug should be discontinued 48 hours before the study; during the treatment it is not recommended to take ethanol, to reduce the risk of adverse events in the gastrointestinal tract
the lowest effective dose with the shortest possible course should be used. In patients with bronchial asthma or other diseases occurring with bronchospasm, Ibuprofen may increase the risk of bronchospasm. The use of the drug in these patients is acceptable only with great caution, and in case of breathing difficulties, you should immediately consult a physician.

Side effects

Overdose

Symptoms of ibuprofen overdose in children: Abdominal pain, nausea, vomiting, lethargy, headache, tinnitus, depression, drowsiness, metabolic acidosis, coma, hemorrhagic diathesis, decreased blood pressure, seizures, apnea, acute renal failure, liver dysfunction, tachycardia, bradycardia, atrial fibrillation, forced diuresis. Children under 5 years of age are especially prone to apnea, coma and seizures.

Serious effects associated with the toxic effects of the drug usually occur after taking a dose greater than 400 mg/kg body weight (i.e., 80 recommended single doses). If an overdose is suspected, seek medical attention immediately.

Treatment in case of overdose: gastric lavage, activated charcoal, alkaline drinking, symptomatic therapy

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