Dolgit, gel 5% 50 g

The drug has a local anesthetic and anti-inflammatory effect. It suppresses the production of inflammatory mediators. It indiscriminately blocks cyclooxygenase (COX-1 and COX-2) and has an inhibitory effect on the synthesis of prostaglandin, prostacyclin and thromboxane.

The analgesic effect is most pronounced for pain of inflammatory nature: the drug reduces pain syndrome in pain at rest and on movement; it reduces morning stiffness and joint swelling; it helps increase range of motion. In addition to its anti-inflammatory effect, ibuprofen reduces platelet aggregation at the site of inflammation, as well as leukocyte migration and release of lysosomal enzymes in the inflamed area.

Ibuprofen penetrates into deeper tissues (subcutaneous tissue, muscles, joints, synovial fluid) and reaches therapeutic concentrations in the skin when the gel is applied. The therapeutic effect in the area of application is achieved by direct distribution through the skin to the target tissues. In a small amount is determined in blood plasma. With the recommended method of application, the concentration in synovial fluid is about 2 µg/ml.

Indications

Inflammatory and degenerative diseases of the musculoskeletal system:
Arthritis (rheumatoid, psoriatic).
Articular syndrome in rheumatism and exacerbation of gout.
Humoscapular periarthritis.
Ankylosing spondylitis (ankylosing spondylitis).
Deforming osteoarthritis.
Osteochondrosis with radicular syndrome.
Radiculitis.
Sciatica.
Myalgia (rheumatic and non-rheumatic origin).
Lumbago.
Tendivit, tenosynovitis, bursitis.
Injuries (sports, industrial, household) without violating the integrity of soft tissues (including dislocations, sprains, ruptures of muscles or ligaments, bruises, post-traumatic swelling of soft tissues).

Pharmacological effect

The drug has a local analgesic and anti-inflammatory effect. Suppresses the production of inflammatory mediators. Indiscriminately blocks cyclooxygenase (COX-1 and COX-2) and has an inhibitory effect on the synthesis of prostaglandin, prostacyclin and thromboxane.

The analgesic effect is most pronounced for pain of an inflammatory nature: the drug weakens the pain syndrome during pain at rest and during movement; reduces morning stiffness and swelling of joints; helps increase range of motion. In addition to the anti-inflammatory effect, ibuprofen reduces platelet aggregation at the site of inflammation, as well as the migration of leukocytes and the release of lysosomal enzymes in the area of ​​inflammation.

When the gel is applied to the skin, ibuprofen penetrates into deeper tissues (subcutaneous tissue, muscles, joints, synovial fluid) and reaches therapeutic concentrations there. The therapeutic effect in the area of ​​application is achieved by direct distribution through the skin into the target tissue. It is detected in small quantities in blood plasma. With the recommended method of application, the concentration in the synovial fluid is about 2 μg/ml.

Special instructions

In severe cases, combined use of the gel externally with the administration of other dosage forms of NSAIDs (parenterally, orally, rectally) is recommended.

Avoid contact of the gel with the eyes and mucous membranes.

The use of the drug does not affect activities that require increased attention, coordination of movements, high speed of mental and physical reactions (for example, in transport drivers, people working with complex mechanisms, etc.).

Active ingredient

Ibuprofen

Composition

100 g of gel contains 5 g of the active substance ibuprofen;

excipients:

isopropanol,

dimethylhydroxymethyldioxolane (Solketal),

poloxamer a;b;c = 101;56;101 (Poloxamer 407, Pluronic F 127),

medium chain triglycerides (Migliol 812),

purified water,

lavender oil,

orange blossom oil (nerol oil).

Pregnancy

The use of the drug during pregnancy and breastfeeding is contraindicated.

Contraindications

Hypersensitivity to ibuprofen, drug components and other NSAIDs; bronchial asthma, urticaria, rhinitis, provoked by taking acetylsalicylic acid; weeping dermatoses, eczema, violations of the integrity of the skin at the site of application of the gel, including infected wounds and abrasions; pregnancy (III trimester), children under 12 years of age.

Side Effects

Usually the drug is well tolerated.

Interaction

Drug interactions with other drugs have not been described.

However, it should be borne in mind that even when applied topically, ibuprofen has a systemic effect, and, theoretically, the simultaneous use of the gel with other NSAIDs may increase side effects.

Overdose

Cases of drug overdose have not been described.

In case of accidental ingestion of the drug, it is necessary to induce vomiting, gastric lavage, and take activated charcoal. Further treatment, if necessary, is symptomatic.

Storage conditions

Store in a dry place, at a temperature of 15-25 °C.

Keep out of the reach of children!

Shelf life

2.5 years.

Manufacturer

Dolorgit GmbH and Co. KG, Germany