The drug has a local anesthetic, anti-inflammatory and anti-edema effect. It suppresses the production of inflammatory mediators. It indiscriminately blocks cyclooxygenase (COX-1 and COX-2) and has inhibitory effect on the synthesis of prostaglandin E2 (PGE2), prostacyclin (PGI2) and thromboxane B2 (TV2). Analgesic effect is most pronounced in pain of inflammatory nature.
Causes reduction or disappearance of pain syndrome, including pain at rest and on movement; reduces morning stiffness and joint swelling. Helps increase range of motion. In addition to its anti-inflammatory effect, ibuprofen reduces platelet aggregation in the inflamed area, as well as migration of leukocytes and release of lysosomal enzymes in the inflamed area.
Ibuprofen penetrates into deeper tissues (subcutaneous tissue, muscles, joints, synovial fluid) and reaches therapeutic concentrations in the skin when the cream is applied. The therapeutic effect in the area of application is achieved by direct distribution through the skin to the target tissues. In a small amount is determined in blood plasma. With the recommended method of application, the concentration in synovial fluid is about 2 µg/ml.
- Inflammatory and degenerative diseases of the musculoskeletal system:
- Arthritis (rheumatoid, psoriatic).
- Joint syndrome in rheumatism and gout exacerbation.
- Bladder’s periarthritis.
- Better’s disease (ankylosing spondylitis).
- Deforming osteoarthritis.
- Osteochondrosis with radicular syndrome.
- Myalgia (rheumatic and non-rheumatic origin).
- Tendivitis, tendovaginitis, bursitis.
- Injuries (sports, industrial, domestic) without violation of the integrity of soft tissue (including sprains, strains, muscle or ligament tears, bruises, post-traumatic soft tissue edema).
100 g of cream contains 5 g of the active ingredient ibuprofen;
How to take, the dosage
The drug should be applied externally.
A 5-10 cm long strip of cream is applied to the skin in the area of pain and rubbed gently until the drug is completely absorbed 2-3 times a day. The course of treatment should not exceed 10 days without medical advice.
The duration of therapy with the drug Dolgit depends on the severity of the disease and the nature of the injury.
Physician should be consulted before using Dolgit cream if other drugs are used.
There have been no interactions with other drugs when ibuprofen is used topically.
The drug should not be applied to open wound surfaces, damaged skin or mucous membranes (avoid eye contact).
In case of ineffectiveness of the current therapy, consult a physician.
In severe cases it is recommended to combine local therapy with oral NSAIDs.
Pediatric use Dolgit in cream form should not be used in children under 12 years of age without medical advice.
– Effect on ability to drive and operate machinery The use of Dolgit cream has no effect on activities requiring increased attention, coordination of movements, high speed mental and physical reactions (including vehicle drivers, car attendants).
Hypersensitivity to ibuprofen, components of the drug and other NSAIDs, soggy dermatosis, eczema, skin integrity disorders (including infected abrasions and wounds) at the site of application of the cream, pregnancy, lactation, children under 14 years of age.
Usually the drug is well tolerated.
Cases of overdose with Dolgit cream have not been described.
Symptoms: nausea and vomiting may occur if the drug is accidentally swallowed.
Treatment: the stomach should be cleared (cause vomiting, take activated charcoal) and see a doctor. Further treatment, if necessary, symptomatic.
Nurofen, Nurofen Express, Brufen, Ibuprofen, Dolgit, Ibuprofen-Chemopharm, Nurofen Forte, MIG 400, Faspik, Nurofen Express Lady, Nurofen Express Forte, Nurofen Children, Next Uno Express, Nurofast
|Conditions of storage|
Store in a dry place at a temperature of 15 ° to 25 ° C.
Dolorgit GmbH & Co.
Buy Dolgit, cream 5% 100 g with delivery to USA, UK, Europe and over 120 other countries.