The drug has a local anesthetic and anti-inflammatory effect. It suppresses the production of inflammatory mediators. It indiscriminately blocks cyclooxygenase (COX-1 and COX-2) and has an inhibitory effect on the synthesis of prostaglandin, prostacyclin and thromboxane.
The analgesic effect is most pronounced for pain of inflammatory nature: the drug reduces pain syndrome in pain at rest and on movement; it reduces morning stiffness and joint swelling; it helps increase range of motion. In addition to its anti-inflammatory effect, ibuprofen reduces platelet aggregation at the site of inflammation, as well as leukocyte migration and release of lysosomal enzymes in the inflamed area.
Ibuprofen penetrates into deeper tissues (subcutaneous tissue, muscles, joints, synovial fluid) and reaches therapeutic concentrations in the skin when the gel is applied. The therapeutic effect in the area of application is achieved by direct distribution through the skin to the target tissues. In a small amount is determined in blood plasma. With the recommended method of application, the concentration in synovial fluid is about 2 µg/ml.
Neck pain, Periarthritis, Rheumatoid arthritis, Back pain, Lumbago, Joint pain (arthralgia), Swelling after injuries and operations, Osteoarthritis, Pain, Myalgia (muscle pain), Pain after injuries and operations, Arthrosis, Arthritis, Sciatica, Neuralgia
- Inflammatory and degenerative diseases of the musculoskeletal system:
- Artritis (rheumatoid, psoriatic).
- Joint syndrome in rheumatism and gout exacerbation.
- Brachial scapular periarthritis.
- Behterew’s disease (ankylosing spondylitis).
- Deforming osteoarthritis.
- Osteochondrosis with radicular syndrome.
- Myalgia (rheumatic and non-rheumatic origin).
- Lumbago .
- Tendicitis, tendovaginitis, bursitis.
- Injuries (sports, industrial, domestic) without violation of the integrity of soft tissue (including sprains, strains, muscle or ligament tears, contusions, post-traumatic soft tissue edema).
100 g of gel contains 5 g of the active ingredient ibuprofen;
poloxamer a;b;c = 101;56;101 (Poloxamer 407, Pluronic F 127),
medium-chain triglycerides (Migliol 812),
orange blossom oil (neroli oil).
How to take, the dosage
OUTSIDE! A 5-10 cm strip of gel is applied to the damaged area and carefully rubbed in gently until completely absorbed 3-4 times a day.
Drug interactions with other drugs have not been described.
However, it should be taken into account that even when used topically ibuprofen has a systemic effect, and, theoretically, when using the gel with other NSAIDs, side effects may increase.
In severe cases it is recommended to combine the use of the gel externally with taking other dosage forms of NSAIDs (parenterally, internally, rectally).
Contact of the gel into the eyes and mucous membranes should be avoided.
The use of the drug has no effect on activities which require increased attention, coordination of movements, high speed of mental and physical reactions (e.g., drivers of vehicles, persons working with complex machines, etc.).
Hypersensitivity to ibuprofen, components of the drug and other NSAIDs; bronchial asthma, urticaria, rhinitis, provoked by taking acetylsalicylic acid; soggy dermatosis, eczema, skin integrity disorders in the application area of the gel, including infected wounds and abrasions; pregnancy (III trimester), children under 12 years old.
Usually the drug is well tolerated.
No cases of overdose of the drug have been described.
In case of accidental ingestion of the drug it is necessary to induce vomiting, gastric lavage, take activated charcoal. Further treatment, if necessary, is symptomatic.
The drug is contraindicated in pregnancy and during breastfeeding.
Nurofen, Nurofen Express, Brufen, Ibuprofen, Dolgit, Ibuprofen-Chemopharm, Nurofen Forte, MIG 400, Faspik, Nurofen Express Lady, Nurofen Express Forte, Nurofen Children, Next Uno Express, Nurofast
|Conditions of storage|
Store in a dry place at 15-25 °C. Store out of reach of children!
Dolorgit GmbH & Co.
gel for external use
Buy Dolgit, gel 5% 50 g with delivery to USA, UK, Europe and over 120 other countries.