Cefecon D for children, rectal 250 mg 10 pcs

Indications

Neuritis, Headache, Toothache, Migraine, Joint pain, Burns, Joint pain (arthralgia), Myalgia (muscle pain), Arthritis, Muscle pain, Flu, Arthrosis, Pain, Neuralgia

Cefekon D 250 mg is used in children from 3 to 12 years as:

• antipyretic in acute respiratory infections, influenza, childhood infections, postvaccination reactions and other conditions accompanied by an increase in body temperature;
• painkiller in pain syndrome of mild to moderate intensity, including.Headache, toothache, muscle pain, neuralgia, pain from injuries and burns.
  

Active ingredient

Paracetamol

Composition

One suppository contains:

The active ingredient:

Paracetamol – 50 mg, 100 mg or 250 mg;

Bases for suppositories:

Solid fat (vitepsol, supposir) – to obtain a suppository weight of 1.25 g.

How to take, the dosage

Rectally, after purging enema or spontaneous bowel emptying. Dosage of Cefecon D is calculated depending on age and body weight, according to the table.

The average single dose is 10-15 mg/kg 2-3 times a day every 4-6 hours.
The maximum daily dose of paracetamol should not exceed 60 mg/kg.

1-3 months (4-6 kg) – 1 sup. 50 mg (50 mg);

3-12 months (7-10 kg) – 1 sup. 100 mg (100 mg);

1 to 3 years (11-16 kg) – 1-2 sups. 100 mg (100-200 mg);

3 to 10 years (17-30 kg) – 1 sip of 250 mg (250 mg);

10 to 12 years (31-35 kg) – 2 sips of 250 mg (500 mg).

Interaction

Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase

The production of hydroxylated active metabolites, which causes the possibility of severe intoxication, even with a small overdose.

Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxic effects. When taken together with salicylates, the nephrotoxic effect of paracetamol increases.

Combination with chloramphenicol, increases the toxic properties of the latter. It enhances the effect of indirect anticoagulants, reduces the effectiveness of uricosuric drugs.

.

Special Instructions

If fever persists for more than 3 days and pain syndrome for more than 5 days should consult a physician.

Avoid simultaneous use of paracetamol with other paracetamol-containing drugs, because it may cause paracetamol overdose.

When using the drug for more than 5-7 days peripheral blood parameters and functional status of the liver should be monitored.

Paracetamol distorts laboratory values for quantitative determination of glucose and uric acid in plasma.

Contraindications

• Hypersensitivity to components of Cefecon D
• age up to 1 month of life.
• With caution:
• disorders of liver and kidney function;
• Jilbert syndrome; Dubin-Johnson and Rotor;
• Blood system disorders (anemia, thrombocytopenia, leukopenia);
• genetic absence of the enzyme glucose-6-phosphate dehydrogenase.

.

Side effects

Gastrointestinal tract disorders: nausea, vomiting, abdominal pain.

Allergic reactions: itching, rash on the skin and mucous membranes, urticaria, Quincke’s edema.

Hematopoietic disorders: anemia, leukopenia, agranulocytosis, thrombocytopenia.

In prolonged use in high doses – hepatotoxic and nephrotoxic effects (interstitial nephritis, papillary necrosis), hemolytic anemia.

.

Overdose

Symptoms:

In the first 24 h after ingestion, skin pallor, nausea, vomiting, anorexia, abdominal pain; impaired glucose metabolism, metabolic acidosis.

The symptoms of hepatic dysfunction may appear 12-48 hours after overdose.

In severe overdose – hepatic failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis.

Hepatotoxic effect in adults occurs when taking 10 g or more.

Treatment:

The administration of SH-group donators and precursors of glutathione synthesis – methionine in 8-9 hours after overdose and N-acetylcysteine in 12 hours.

The need for further therapeutic measures (further methionine administration, intravenous N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration.

.

Similarities

Efferalgan, Cefekon D, Paracetamol, Paracetamol for children, Paracetamol Renewal, Paracetamol, tablets 500 mg 10 pcs