Ambroxol-Chemopharm, syrup 15 mg/5 ml 100 ml
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Mucolytic agent, stimulates prenatal lung development (increases synthesis, secretion of surfactant and blocks its breakdown).
It has secretomotor, secretolytic and expectorant action; stimulates serous gland cells of the mucous membrane of the bronchi, increases the mucous secretion and secretion of surfactant (surfactant) in the alveoli and bronchi; normalizes the disturbed ratio of serous and mucous components of sputum.
By activating hydrolyzing enzymes and increasing the release of lysosomes from Clark cells, reduces the viscosity of sputum.
It increases motor activity of micturate epithelium, increases mucociliary transport.
After oral administration the action comes in 30 minutes and lasts for 6-12 hours.
Absorption is high (by all routes of administration), maximum concentration in blood plasma (Tcmax) – after 2 hours, binding to plasma proteins – 80%. It penetrates through the blood-brain barrier (BBB), placental barrier, excreted with breast milk.
Metabolism – in liver, forms dibromanthranilic acid and glucuron conjugates. Period of half-life excretion (T1/2) – 7-12 hours. Renal excretion: 90% as water-soluble metabolites, unchanged – 5%.
Half-life is increased in severe chronic renal failure, but does not change in liver function disorders.
Diseases of the respiratory tract with the production of viscous sputum: acute and chronic bronchitis, pneumonia, chronic obstructive pulmonary disease, bronchial asthma with sputum retention, bronchiectatic disease.
5 ml of syrup contain the active substance:
Ambroxol hydrochloride 15 mg;
Hyethylose (hydroxyethylcellulose 6000 mPas)
How to take, the dosage
Both effervescent tablets and syrup are taken orally after meals.
1 or 1/2 effervescent tablet is dissolved in a glass of water (200 ml). The tablets should not be swallowed, chewed or sucked by mouth.
Adults and children over 12 years: during the first 2-3 days, 1/2 effervescent tablet (30 mg) 3 times a day or 1 tablet 60 mg in the morning and 1/2 tablet (30 mg) in the evening; in subsequent days, 1/2 effervescent tablet (30 mg) 2 times a day.
If necessary to intensify the therapeutic effect during the first 2-3 days it is possible to administer 60 mg (1 effervescent tablet) 2 times a day.
It is not recommended to take the preparation more than 4-5 days without prescription.
Syrup 15 mg/5 ml (1 measuring spoon – 5 ml)
Adults and children over 12 years old: During the first 2-3 days 10 ml (2 measuring spoons) 3 times a day, then 10 ml (2 measuring spoons) 2 times a day. In severe cases the dose is not reduced during the whole course of treatment.
Children: from 5 to 12 years old – 5 ml (1 measuring spoon) 2-3 times a day, from 2 to 5 years old – 2.5 ml (1/2 measuring spoon) 3 times a day, to 2 years old – 2.5 ml (1/2 measuring spoon) 2 times a day.
For children under 1 year old the drug may be prescribed only after consultation with the physician.
Ambroxol-Hemofarm in syrup form should be taken orally with drinking fluids.
Open bottle should be stored for 4 weeks.
Receiving the drug for more than 4-5 days only under the supervision of a doctor.
Compatible with drugs that inhibit labor activity.
Combined use with anti-cough medications leads to difficulty in expectoration of sputum on the background of reduced coughing.
It increases penetration of amoxicillin, cefuroxime, erythromycin and doxycycline into the bronchial secretion.
It should not be combined with anti-cough drugs that make it difficult to expectorate sputum.
Hypersensitivity to all components of the drug; rare hereditary diseases such as:
galactose intolerance, lactase deficiency or glucose-galactose malabsorption (for effervescent tablets),
pregnancy (first trimester), phenylketonuria (for effervescent tablets); children under 12 years of age (effervescent tablets).
Allergic reactions: skin rash, urticaria, angioneurotic edema, in some cases – allergic contact dermatitis, anaphylactic shock.
Rarely – weakness, headache, diarrhea, dry mouth and respiratory tract, exanthema, rhinorrhea, constipation, dysuria. With prolonged use in high doses – gastralgia, nausea, vomiting.
Symptoms: nausea, vomiting, diarrhea, dyspepsia, gastralgia are possible.
Treatment: induction of vomiting, gastric lavage during the first 1-2 hours after taking the drug; intake of fat-containing products, symptomatic therapy.
Preclinical trials and extensive clinical experience of use have shown no adverse effects of treatment with the drug in pregnancy.
If it is necessary to use Lazolvan® in II-III trimesters of pregnancy, the potential therapy for the mother and the possible risk to the fetus should be assessed
Ambrohexal, Lazolvan, Halixol, Ambroxol, Ambrobene, Orvis Broncho, ORVIS, Lazolvan Max, Zvezdochka, Zvezdochka for colds
5 years. Do not use after the expiration date on the package.
|Conditions of storage|
List B. Syrup – Store in the dark place at 15 to 25 ° C. Keep out of reach of children!
Chemopharm A.D., Serbia
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