Ambroxol-Chemopharm, syrup 15 mg/5 ml 100 ml

Mucolytic agent, stimulates prenatal lung development (increases synthesis, secretion of surfactant and blocks its breakdown).

It has secretomotor, secretolytic and expectorant action; stimulates serous gland cells of the mucous membrane of the bronchi, increases the mucous secretion and secretion of surfactant (surfactant) in the alveoli and bronchi; normalizes the disturbed ratio of serous and mucous components of sputum.

By activating hydrolyzing enzymes and increasing the release of lysosomes from Clark cells, reduces the viscosity of sputum.

It increases motor activity of micturate epithelium, increases mucociliary transport.

After oral administration the action comes in 30 minutes and lasts for 6-12 hours.

Absorption is high (by all routes of administration), maximum concentration in blood plasma (Tcmax) – after 2 hours, binding to plasma proteins – 80%. It penetrates through the blood-brain barrier (BBB), placental barrier, excreted with breast milk.

Metabolism – in liver, forms dibromanthranilic acid and glucuron conjugates. Period of half-life excretion (T1/2) – 7-12 hours. Renal excretion: 90% as water-soluble metabolites, unchanged – 5%.

Half-life is increased in severe chronic renal failure, but does not change in liver function disorders.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Compatible with drugs that inhibit labor activity.

Combined use with anti-cough medications leads to difficulty in expectoration of sputum on the background of reduced coughing.

It increases penetration of amoxicillin, cefuroxime, erythromycin and doxycycline into the bronchial secretion.

Special Instructions

Contraindications

Side effects

Overdose

Symptoms: nausea, vomiting, diarrhea, dyspepsia, gastralgia are possible.

Treatment: induction of vomiting, gastric lavage during the first 1-2 hours after taking the drug; intake of fat-containing products, symptomatic therapy.

Pregnancy use

Preclinical trials and extensive clinical experience of use have shown no adverse effects of treatment with the drug in pregnancy.

Similarities