Acyclovir, cream 5% 5 g

Pharmacotherapeutic group

Antiviral drug

ATX code: S01AD

Pharmacodynamics:

Aciclovir is active in vitro against Herpes simplex virus types 1 and 2 Varicella zoster virus Epstein-Barr virus and cytomegaloviruses. Thymidine kinase of virus-infected cells actively converts acyclovir into acyclovir mono-di- and triphosphate through a series of reactions. The latter interacts with the viral DNA polymerase and is incorporated into the DNA that is synthesized for new viruses. Thus “defective” viral DNA is formed which leads to suppression of replication of new generations of viruses.

Pharmacokinetics:

When applied externally it is practically not absorbed through intact skin and is not determined in blood and urine. When applied to the affected skin, absorption is moderate.

In patients with normal renal function the concentration in blood serum is up to 028 mkg/ml in patients with chronic renal insufficiency – up to 078 mkg/ml. It is excreted by the kidneys (up to 94% of the daily dose).

Indications

Skin infections caused by Herpes simplex virus types 1 and 2 including lip herpes.

Active ingredient

Acyclovir

Composition

100 g of the cream contains:

The active ingredient: acyclovir – 5.00 g

The excipients: Propylene glycol – 40.00 g, poloxamer 407 – 1.00 g, glyceryl monostearate 40-55 type II – 0.75 g, macrogol 20 stearate type 1-0.75 g, emulsifier №1 – 7.50 g, dimethicone 100 – 1.00 g, petroleum jelly – 11.50 g, liquid paraffin (Vaseline oil) – 5.00 g, water – to 100.0 g.

How to take, the dosage

Externally.

Adults. The drug is applied 5 times a day (every 4 hours) in a thin layer on the affected and adjacent skin areas. The cream may be applied with a cotton swab or clean hands to avoid further infection of affected areas. It is important to begin treatment as soon as possible at the onset of the disease, preferably during the prodromal period.

Treatment should continue until either the blisters have crusted over or they have completely healed.

The duration of therapy is on average 5 days and should not exceed 10 days.

Interaction

When used externally, no interaction with other drugs was found.

Special Instructions

In order to achieve maximum therapeutic effect, it is necessary to start using the product as soon as possible after the onset of infection (at the first signs of the disease: burning, tingling, tingling sensation and redness).

Influence on the ability to drive vehicles and machines: Not studied.

Contraindications

Hypersensitivity to acyclovir and other components of the drug.

Cautions:

Pregnancy period of breastfeeding.

Side effects

Adverse reactions are presented in accordance with the classification of the World Health Organization (WHO) according to the frequency of occurrence: very common (≥ 1/10) common (≥ 1/100 to < 1/10) infrequent (≥ 1/1000 to < 1/100) rare (≥ 1/10 000 to < 1/1 000) very rare (< 1/10 000) frequency is unknown (to establish the frequency of which there are not enough data).

Skin disorders:

Infrequent: burning sensation after application of the cream which subsides with time dry skin itching tingling at the site of application peeling of the skin;

Rare: erythema contact dermatitis at the site of application.

The immune system:

Very rarely: anaphylactic reactions including angioedema and urtic rash.

If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Symptoms: (in case of accidental ingestion): headache neurological disorders shortness of breath nausea vomiting diarrhea impaired kidney function.

Treatment: maintenance of vital functions hemodialysis.

Pregnancy use

In pregnancy and during breastfeeding, use only if the estimated benefit to the mother exceeds the potential risk to the fetus and child.

Similarities

Zovirax, Vivorax, Acyclovir-Acri, Acyclovir, Herperax, Acyclovir Belupo, Acyclovir Sandoz