Aciclovir, 5% ointment 10 g

The antiviral drug is a synthetic analog of thymidine nucleoside.

In infected cells containing viral thymidine kinase is phosphorylated and converted into acyclovir monophosphate. Under the influence of guanylate cyclase acyclovir monophosphate is converted into diphosphate and under the influence of several cellular enzymes into triphosphate. High selectivity and low toxicity for humans is caused by the absence of necessary enzyme for formation of acyclovir triphosphate in intact cells of macroorganism.

Aciclovir triphosphate, “embedding” into the DNA synthesized by the virus, blocks the reproduction of the virus. Specificity and very high selectivity of action are also due to its preferential accumulation in cells affected by the herpes virus.

Highly active against Herpes simplex viruses of types 1 and 2; viruses causing chicken pox and shingles (Varicella zoster); Epstein-Barr virus (types of viruses are specified in ascending order of MAC value of acyclovir).
Moderately active against CMV.

In herpes it prevents formation of new rash elements, reduces the probability of cutaneous dissemination and visceral complications, accelerates crust formation, reduces pain in the acute phase of herpes zoster.

Indications

Herpes simplex of the skin and mucous membranes, genital herpes (primary and recurrent);
localized herpes zoster (auxiliary treatment).

Pharmacological effect

The antiviral drug is a synthetic analogue of thymidine nucleoside.

In infected cells containing viral thymidine kinase, phosphorylation occurs and is converted to acyclovir monophosphate. Under the influence of acyclovir guanylate cyclase, monophosphate is converted into diphosphate and, under the action of several cellular enzymes, into triphosphate. High selectivity of action and low toxicity to humans are due to the absence of the necessary enzyme for the formation of acyclovir triphosphate in intact cells of the macroorganism.

Acyclovir triphosphate, “integrating” into the DNA synthesized by the virus, blocks the reproduction of the virus. The specificity and very high selectivity of the action are also due to its predominant accumulation in cells affected by the herpes virus.

Highly active against Herpes simplex virus types 1 and 2; the virus that causes chickenpox and herpes zoster (Varicella zoster); Epstein-Barr virus (types of viruses are indicated in increasing order of the MIC of acyclovir).
Moderately active against CMV.

In case of herpes, it prevents the formation of new rash elements, reduces the likelihood of skin dissemination and visceral complications, accelerates the formation of crusts, and reduces pain in the acute phase of herpes zoster.

Special instructions

Acyclovir should be prescribed with caution to patients with impaired renal function and elderly patients due to an increase in the half-life of acyclovir.

When using the drug, it is necessary to ensure the supply of a sufficient amount of fluid.

The ointment is not recommended to be applied to the mucous membranes of the mouth, eyes, and genitals, because the development of severe local inflammation is possible.

The earlier it is started, the higher the effectiveness of treatment when using the ointment.

In patients with immunodeficiency, with multiple repeated courses of treatment, viral resistance to acyclovir sometimes develops.

When taking the drug, kidney function should be monitored (blood urea and plasma creatinine levels).

Active ingredient

Acyclovir

Composition

1 g of ointment for external use contains:

active ingredient:

acyclovir 50 mg

Pregnancy

The use of the drug during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

Acyclovir crosses the placental barrier and accumulates in breast milk. If it is necessary to take acyclovir during lactation, interruption of breastfeeding is required.

Contraindications

Hypersensitivity.
With caution. Pregnancy, lactation period.

Side Effects

Local reactions: when using the ointment, redness, itching, peeling, burning or tingling are possible.

Storage conditions

The drug in the form of an ointment should be stored in a dry place, protected from light, at a temperature of 8° to 15°C.

Manufacturer

Ozon, Russia