Acyclovir, cream 5% 5 g

Pharmacotherapeutic group

Antiviral drug

ATX code: S01AD

Pharmacodynamics:

Aciclovir is active in vitro against Herpes simplex virus types 1 and 2 Varicella zoster virus Epstein-Barr virus and cytomegaloviruses. Thymidine kinase of virus-infected cells actively converts acyclovir into acyclovir mono-di- and triphosphate through a series of reactions. The latter interacts with the viral DNA polymerase and is incorporated into the DNA that is synthesized for new viruses. Thus “defective” viral DNA is formed which leads to suppression of replication of new generations of viruses.

Pharmacokinetics:

When applied externally it is practically not absorbed through intact skin and is not determined in blood and urine. When applied to the affected skin, absorption is moderate.

In patients with normal renal function the concentration in blood serum is up to 028 mkg/ml in patients with chronic renal insufficiency – up to 078 mkg/ml. It is excreted by the kidneys (up to 94% of the daily dose).

Indications

Skin infections caused by Herpes simplex virus types 1 and 2 including herpes labialis.

Pharmacological effect

Pharmacotherapeutic group

Antiviral agent

ATX code: S01AD

Pharmacodynamics:

Acyclovir is active in vitro against Herpes simplex types 1 and 2 of the Varicella zoster virus, Epstein-Barr virus and cytomegaloviruses. Thymidine kinase of virus-infected cells, through a series of sequential reactions, actively converts acyclovir into acyclovir mono-di- and triphosphate. The latter interacts with the viral DNA polymerase and is integrated into the DNA that is synthesized for new viruses. In this way, “defective” viral DNA is formed, which leads to the suppression of the replication of new generations of viruses.

Pharmacokinetics:

When used externally, it is practically not absorbed through intact skin and is not detected in the blood and urine. When applied to affected skin, absorption is moderate.

In patients with normal renal function, the concentration in the blood serum is up to 028 mcg/ml; in patients with chronic renal failure – up to 078 mcg/ml. Excreted by the kidneys (up to 94% of the daily dose).

Special instructions

To achieve the maximum therapeutic effect, it is necessary to start using the drug as soon as possible after the onset of infection (at the first signs of the disease: burning, itching, tingling, feeling of tension and redness).

The cream is not recommended to be applied to the mucous membranes of the mouth, eyes, nose and vagina, as severe local inflammation may develop. Patients with immunodeficiency conditions should follow the doctor’s recommendations when treating any infectious diseases.

Impact on the ability to drive vehicles. Wed and fur.:
Not studied.

Active ingredient

Acyclovir

Composition

100 g of cream contains:

Active substance: acyclovir – 5.00 g

Excipients: propylene glycol – 40.00 g, poloxamer 407 – 1.00 g, glyceryl monostearate 40-55 type II – 0.75 g, macrogol 20 stearate type 1-0.75 g, emulsifier No. 1 – 7.50 g, dimethicone 100 – 1.00 g, petroleum jelly – 11.50 g, liquid paraffin (vaseline oil) – 5.00 g, water – up to 100.0 g.

Pregnancy

During pregnancy and breastfeeding, it is used only if the expected benefit to the mother outweighs the potential risk to the fetus and child.

Contraindications

Hypersensitivity to acyclovir and other components of the drug.

With caution:

Pregnancy period of breastfeeding.

Side Effects

Adverse reactions are presented in accordance with the World Health Organization (WHO) classification according to the frequency of development depending on the degree of frequency of occurrence: very often (≥ 1/10) often (from ≥ 1/100 to < 1/10) infrequently (from ≥ 1/1000 to < 1/100) rarely (from ≥ 1/10,000 to < 1/1 000) very rare (< 1/10,000) frequency unknown (to establish the frequency of which there is insufficient data).

From the skin:

Uncommon: burning sensation after applying the cream, which disappears over time, dry skin, itching, tingling at the site of application, peeling of the skin;

Rare: erythema, contact dermatitis at the application site.

From the immune system:

Very rare: anaphylactic reactions including angioedema and urticaria.

If any of the side effects indicated in the instructions get worse or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

When used externally, no interactions with other drugs were detected.

Overdose

Symptoms: (if accidentally swallowed): headache neurological disorders shortness of breath nausea vomiting diarrhea impaired renal function.

Treatment: maintaining vital functions hemodialysis.

Storage conditions

In a place protected from light at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life

3 years. Do not use after expiration date.

Manufacturer

Ozon, Russia