🐾 Sulfetrisan solution, bottle 100 ml

Sulfetrisan is a combined antibacterial drug for parenteral use. The combination of the components of the drug provides a wide range of its antibacterial action against Gram-positive and Gram-negative microorganisms. Erythromycin is an antibiotic of macrolide group, the mechanism of bacteriostatic action of which is associated with blocking of protein synthesis and disruption of formation of peptide bonds between amino acid molecules in the microbial cell. It is active against Gram-positive (Stapylococcus spp., Streptococcus spp., Corynebacterium spp., Clostridium spp.) and some Gram-negative bacteria (Pasteurella spp., Haemophilus spp. and Mycoplasma spp.). The action of erythromycin is enhanced by a combination of sulfadimethoxin and trimethoprim, which, along with action on Gram-positive microflora, are highly active against Gram-negative bacteria (Escherichia coli, Salmonella spp., Shigella spp., Haemophilus spp, Klebsiella spp.,). Having a synergistic effect and increasing the activity of each other through a sequential effect on the metabolism of n-amino-benzoic acid and folic acid in the microbial cell, the combination of sulfadimethoxin and trimethoprim is effective against microorganisms, poorly sensitive to sulfonamides. Dexamethasone is a synthetic glucocorticosteroid and has anti-inflammatory, desensitizing and antitoxic effects. After intramuscular injection of the drug, its antibacterial components are easily absorbed from the injection site and penetrate into most organs and tissues of the body, reaching maximum concentrations after 2-3 hours. Erythromycin is excreted mainly with bile and partially (about 15%) with urine in unchanged form, trimethoprim and sulfodimethoxin – mainly with urine in unchanged form and as metabolites (15-29%), dexamethasone – mainly as metabolites with urine (about 75%) and bile.

Indications

Sulfur for animals is an additional source of sulfur to the daily diet, it is also used in case of metabolic disorders, to prevent skin and hair diseases in dogs, cats, decorative rabbits and rodents. Addition to daily diet accelerates hair growth (especially during moulting), contributes to its shine, intensive pigmentation, prevents hair breakage and dandruff.

Active ingredient

Sulfadimethoxin,erythromycin,trimethoprim,dexamethasone

Composition

Sulfetrisan 1 ml contains as active ingredients sulfadimethoxin 200 mg, erythromycin thiocyanate 50 mg, trimethoprim 18 mg and dexamethasone 0.1 mg, as well as auxiliary components: benzocaine 1.5 mg, sodium hydroxide 2.92 mg, dimethylacetamide 0.18 ml, dimethylformamide 0.15 ml, dimethyl sulfoxide 0.05 ml, water for injection 0.2 ml and propylene glycol to 1 ml.

How to take, the dosage

Sulfetrisan is administered to animals at intervals of 12-24 hours (depending on severity of the disease course) deeply intramuscularly for 3-5 days at a dose of 1 ml per 10 kg of animal weight. The maximum volume of Sulfetrisan to be administered to an animal in one place shall not exceed 20 ml.

Contraindications

Contraindication to the use of Sulfetrisan is individual hypersensitivity of the animal to the components of the drug, glucose-6-phosphate dehydrogenase deficiency, hepatic and/or renal failure.

Side effects

When using Sulfetrisan in accordance with these instructions no side effects and complications are usually observed. Some animals experience soreness at the injection site, which disappears spontaneously and does not require application of drugs. In view of increased specific sensitivity of goats to components of the drug, Sulfetrisan should be used with special caution under control of veterinarian. In case of allergic reactions the use of the drug shall be discontinued and the animal shall be prescribed antihistamines and symptomatic drugs.