Zovirax, cream 5% 5 g

Antiviral drug for external and local use. Acyclovir is active against Herpes simplex 1 and 2 types, Varicella zoster virus, Epstein-Barr virus and cytomegaloviruses.

Thymidinkinase of virus-infected cells through a series of sequential reactions actively converts acyclovir into acyclovir mono-, di- and triphosphate. The latter interacts with the viral DNA polymerase and is incorporated into the DNA that is synthesized for new viruses. Thus, “defective” viral DNA is formed, which leads to suppression of replication of new generations of viruses.

Indications

Infections of the skin and mucous membranes caused by the Herpes simplex virus types 1 and 2, incl. herpes lips

Pharmacological effect

Antiviral drug for external and local use. Acyclovir is active against Herpes simplex types 1 and 2, Varicella zoster virus, Epstein-Barr virus and cytomegaloviruses.

Thymidine kinase of virus-infected cells, through a series of sequential reactions, actively converts acyclovir into mono-, di- and triphosphate of acyclovir. The latter interacts with the viral DNA polymerase and is integrated into the DNA that is synthesized for new viruses. Thus, “defective” viral DNA is formed, which leads to the suppression of the replication of new generations of viruses.

Special instructions

To achieve the maximum therapeutic effect, it is necessary to use the drug at the first signs of the disease (burning, itching, tingling, feeling of tension and redness).

In case of severe manifestations of herpes of the lips, it is recommended to consult a doctor.

The cream is not recommended to be applied to the mucous membranes of the mouth and eyes, because local inflammation may develop.

When treating genital herpes, it is recommended to avoid sexual intercourse or use condoms, because the use of acyclovir does not prevent sexual transmission of the virus.

Patients with immunodeficiency should follow the doctor’s recommendations when treating any infectious diseases.

Active ingredient

Acyclovir

Composition

Active ingredient:

Acyclovir 5 g.

Excipients:

Propylene glycol,

white soft paraffin,

cetostearyl alcohol,

liquid paraffin,

poloxamer 407 sodium,

lauryl sulfate,

dimethicone,

purified water.

Pregnancy

There have been no adequate and strictly controlled clinical studies of the safety of the drug during pregnancy.

Use is indicated only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

Contraindications

Hypersensitivity to acyclovir and other components of the drug.

Side Effects

Local reactions: sometimes – short-term redness, itching, peeling, burning or tingling in the areas where the drug was applied.

Allergic reactions: rarely – allergic dermatitis (usually associated with a reaction to excipients); in isolated cases – Quincke’s edema.

Interaction

No interactions of Zovirax® with other drugs have been identified.

Overdose

There is no data on an overdose of Zovirax®.

Clinical pharmacology

With repeated use of the cream, systemic absorption is minimal.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25°C; do not freeze.

Shelf life

3 years.

Manufacturer

Glaxo Welcome Operations, UK