Amlorus, tablets 5 mg 30 pcs

Amlorus is a dihydropyridine derivative, a II generation “slow” calcium channel blocker with antianginal and hypotensive effects. Binding to dihydropyridine receptors, it blocks calcium channels, reduces transmembrane transfer of calcium ions into the cell (more in vascular smooth muscle cells than in cardiomyocytes).

Indications

Arterial hypertension (monotherapy or in combination with other antihypertensive agents: diuretics, beta-adrenoblockers, ACE (angiotensin-converting enzyme) inhibitors).

Active ingredient

Amlodipine

Composition

One tablet contains amlodipine besylate (in terms of amlodipine) – 5 mg;

How to take, the dosage

Amlorus is taken orally.
In arterial hypertension and angina pectoris the initial dose is 5 mg once daily. If necessary, the dose may be increased up to 10 mg once a day.
In arterial hypertension, the maintenance dose may be 5 mg per day. In vasospastic angina (Prinzmetal’s angina), 5-10 mg once daily.

Dose changes are not required when concomitantly administered with thiazide diuretics, beta-adrenoblockers and angiotensin-converting enzyme (ACE) inhibitors. No dose changes are required in patients with renal insufficiency, in patients with hepatic impairment and elderly patients – the initial dose in arterial hypertension may be 2.5 mg.

Interaction

Microsomal oxidation inhibitors increase the plasma concentration of amlodipine, increasing the risk of side effects, while microsomal liver enzyme inducers decrease it.

Special Instructions

During treatment it is necessary to control body weight and sodium intake, prescribing an appropriate diet.