Xylong Kids, spray 0.05 mg+5 mg/dose 15 ml

Pharmacotherapeutic group: anticongestant

ATC code: R01AB

Pharmacodynamics:

Xylometazoline belongs to the group of local vasoconstrictors (decongestants) with alpha-adrenomimetic activity causes narrowing of the blood vessels of the nasal cavity mucosa restores the patency of nasal passages facilitates nasal breathing. The action of the drug usually comes within a few minutes after application and lasts up to 10 hours.

Dexpanthenol is a B vitamin and a derivative of pantothenic acid. Dexpanthenol converts in the body to pantothenic acid which is part of coenzyme A and is involved in the processes of acetylation, carbohydrate and fat metabolism in the synthesis of acetylcholine, corticosteroids, porphyrins; it stimulates skin mucous membrane regeneration, normalizes cellular metabolism, accelerates mitosis and increases the strength of collagen fibers. It has a regenerating metabolic and mild anti-inflammatory effect.

Pharmacokinetics:

Xylomethasoline is practically not absorbed when applied topically, plasma concentrations are so low that they cannot be determined by modern analytical methods.

Dexpanthenol when applied topically is rapidly absorbed by the skin and converted to pantothenic acid binds to plasma proteins (mainly beta globulin and albumin). Its concentration in blood is 05-1 mg/L in serum is 100 µg/L. Pantothenic acid is not metabolized in the body (except for inclusion in Co-A) is excreted unchanged.

Indications

Active ingredient

Composition

In one dose:

Active ingredients: xylometazoline hydrochloride – 0.050 mg, dexpanthenol – 5.000 mg.

Excipients: sodium citrate dihydrate – 0.509 mg, sodium chloride – 0.250 mg, hypromellose – 0.100 mg, benzalkonium chloride – 0.015 mg, citric acid monohydrate – 0.350 mg, purified water to 100 µl.

How to take, the dosage

Intranasally.

For children 2 to 6 years of age

Remove the protective cap from the nebulizer. The bottle is ready to use.

Before first use, squeeze the sprayer a few times until an even spray pattern appears.

The bottle should be held upright when using the spray.

You should breathe in through your nose easily while spraying. One injection into each nasal passage 3^ times a day. The duration of therapy is 5-7 days.

Do not use for more than 7 days. The duration of use of the drug in children is determined after consultation with a physician.

Repeated use is possible only after a break of several days.

If after 5 days of treatment, no improvement or worsening of symptoms or new symptoms occur, consult a physician. Use the drug only according to the directions, routes of administration and dosage indicated.

Interaction

Special Instructions

Nasal passages should be cleaned before use.

The duration of use of the drug in children is determined after consultation with the doctor.

When the drug is used according to these instructions for use, it does not affect the ability to drive vehicles and machines, but if there are any adverse events, the patient should not perform the mentioned activities.

Contraindications

Hypersensitivity to the components of the drug arterial hypertension tachycardia marked atherosclerosis hypertheriosis glaucoma atrophic rhinitis dry rhinitis porphyria prostatic hyperplasia brain surgery (history) simultaneous use with monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants childhood age under 2 years.

Diabetes mellitus pheochromocytoma cardiovascular disease (including coronary heart disease) hypersensitivity to the action of adrenergic drugs accompanied by insomnia dizziness arrhythmia tremor increased blood pressure.

Side effects

The undesired phenomena are listed below according to anatomophysiological classification and frequency of occurrence.

The frequency of occurrence is defined as follows: very common (≥ 1/10) common (≥ 1/100 to < 1/10) infrequent (≥ 1/1000 to < 1/100) rare (≥ 1/10000 to < 1/1000) very rare (< 1/10000) unknown (frequency based on available data is unknown).

Nervous system disorders:

Very rare: restlessness insomnia headache fatigue (drowsiness) hallucinations (mostly in children).

Cardiovascular system disorders:

Rarely: sensation of palpitations tachycardia increased blood pressure.

Very rare: arrhythmia

Respiratory system disorders:

Very rare: nasal mucosal edema hypersecretion nasal bleeding.

Prevalence unknown: burning and dryness of the nasal mucosa sneezing.

Muscular system disorders:

Very rare: seizures (especially in children).

Immune system disorders:

Very rare: allergic reactions (angioedema skin rash itching).

If any of the side effects listed in the instructions worsen or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

In cases of overdose or accidental oral administration the following symptoms may occur: mydriasis nausea vomiting cyanosis fever convulsions tachycardia impaired heart rhythm vascular failure cardiac arrest hypertension pulmonary edema respiratory dysfunction hallucinations.

Patients may also experience CNS symptoms of depression accompanied by drowsiness, decreased body temperature, bradycardia, shock, respiratory arrest and coma.

Treatment

Application of activated charcoal gastric lavage oxygen ventilation. For reduction of blood pressure, 5 mg of phentolamine in 09% sodium chloride solution by slow intravenous injection or 100 mg of phentolamine orally is prescribed. Vasoconstrictors are contraindicated. If necessary, antipyretics and anticonvulsants are used.

Pregnancy use

The drug should not be used in pregnancy.

The use of the drug during breastfeeding should be avoided.

Similarities