Xylong, spray 0.1 mg+5 mg/dose 15 ml
€7.74 €6.77
Xylometazoline belongs to the group of local vasoconstrictors (decongestants) with alpha-adrenomimetic activity, causes narrowing of the blood vessels of the nasal cavity mucosa, restores the patency of nasal passages, facilitates nasal breathing. The action of the drug usually comes within a few minutes after application and lasts up to 10 hours.
Dexpanthenol is a vitamin of group B – a derivative of pantothenic acid.
Dexpanthenol is converted by the body into pantothenic acid, which is part of coenzyme A (Co-A) and is involved in the processes of acetylation, carbohydrate and fat metabolism, the synthesis of acetylcholine, corticosteroids, porphyrins; It stimulates skin and mucous membranes regeneration, normalizes cell metabolism, accelerates mitosis and increases collagen fibers strength.
It has regenerative, metabolic and mild anti-inflammatory effect.
Pharmacokinetics
Xylometazoline is almost not absorbed during topical application and its concentration in plasma is so low that it cannot be determined by modern analytical methods.
Dexpanthenol when applied topically is quickly absorbed by skin and converted into pantothenic acid, binds to plasma proteins (mainly beta-globulin and albumin). Its concentration in blood is 0.5-1 mg/l, in blood serum – 100 µg/l.
Pantothenic acid is not metabolized in the body (except for inclusion in Co-A) and excreted unchanged.
Indications
It is used for acute respiratory diseases with rhinitis symptoms, acute allergic rhinitis, vasomotor rhinitis, sinusitis, otitis media (as a part of combined therapy to reduce nasopharyngeal mucosa edema), to facilitate rhinoscopy, restore disturbed nasal breathing; after surgical interventions in the nasal cavity.
Active ingredient
Xylometazoline, [Dexpanthenol]
Composition
Per dose:
Active ingredients:
- xylometazoline hydrochloride – 0.100 mg,
- dexanthenol – 5.000 mg.
Excipients:
- sodium citrate dihydrate – 0.509 mg,
- sodium chloride – 0.250 mg,
- hypromellose – 0.100 mg, <
- benzalkonium chloride – 0.015 mg,
- citric acid monohydrate – 0.350 mg,
- water purified to 100 µl.
.
How to take, the dosage
Intranasal.
Remove the protective cap. The bottle is ready for use.
Before the first use or after a long break in use, press the dosing nozzle several times until an even spray. When using the spray it is necessary to hold the bottle upright.
In order to facilitate the precise dosing of the product when you press the dosing nozzle it is necessary to put it down to the stop.
During the injection it is necessary to inhale easily through the nose. One injection into each nostril 3-4 times a day. The therapy duration is 5-7 days.
It should not be used more than 7 days. The duration of the drug administration in children is determined after consulting the doctor.
Reapplication is possible only after the break of several days.
If in 5 days of treatment no improvement occurs or the symptoms worsen or new symptoms appear it is necessary to consult the doctor. Use the drug only according to the indications, the method of administration and in the doses specified in the instructions.
Interaction
Concomitant use of MAO inhibitors and tricyclic antidepressants may result in increased blood pressure due to the effects of these drugs on the cardiovascular system.
Special Instructions
Nasal passages should be cleaned before use. Duration of use of the drug in children is determined after consultation with a physician.
Impact on the ability to drive vehicles and mechanisms
When using the drug in accordance with these instructions for use, the drug does not affect the ability to drive vehicles, mechanisms, but if any adverse events occur, one should refrain from performing the specified activities.
Contraindications
Hypersensitivity to the components of the drug, arterial hypertension, tachycardia, marked atherosclerosis, hypertheriosis, glaucoma, atrophic rhinitis, dry rhinitis, porphyria, prostatic hyperplasia, brain surgery (in anamnesis), concomitant use with monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants, pregnancy, breastfeeding, children under 6 years of age.
With caution
Diabetes mellitus, pheochromocytoma, diseases of the cardiovascular system (including coronary heart disease), hypersensitivity to the action of adrenergic drugs, accompanied by insomnia, dizziness, arrhythmias, tremors, increased blood pressure.
Side effects
The undesirable phenomena presented below are listed according to anatomico-physiological classification and frequency of occurrence.
Frequency is defined as follows: very common (≥1/10), common (≥1/100 to < 1/10), infrequent (≥1/1000 to < 1/100), rare (≥1/10000 to < 1/1000), very rare (< 1/10000), frequency not known (cannot be estimated based on available data).
Nervous system disorders:
Very rare: restlessness, insomnia, headache, fatigue (drowsiness), hallucinations (mainly in children).
Cardiovascular system disorders:
Rare: palpitations, tachycardia, increased blood pressure.
Very rarely: arrhythmia
Respiratory system disorders:
Very rarely: nasal mucous membrane edema, hypersecretion, nasal bleeding.
Frequency unknown: burning and dryness of nasal mucosa, sneezing.
Musculoskeletal system disorders:
Very rare: seizures (especially in children).
Immune system disorders:
Very rare: allergic reactions (angioedema, skin rash, itching).
If any of the side effects listed in the instructions are aggravated, or you notice any other side effects not specified in the instructions, inform the doctor.
Overdose
In cases of overdose or accidental oral administration the following symptoms may occur: mydriasis, nausea, vomiting, cyanosis, fever, seizures, tachycardia, heart rhythm disorders, vascular failure, cardiac arrest, hypertension, pulmonary edema, respiratory depression, hallucinations.
Patients may also show symptoms of CNS depression accompanied by drowsiness, decreased body temperature, bradycardia, shock, respiratory arrest and coma.
Treatment.
Use of activated charcoal, gastric lavage, oxygen ventilation. In order to decrease blood pressure 5 mg of phentolamine in 0.9% sodium chloride solution is administered by slow intravenous injection or 100 mg of phentolamine orally.
Vasoconstrictors are contraindicated. If necessary, antipyretics and anticonvulsants are used.
Pregnancy use
The drug is contraindicated in pregnancy and during breast-feeding.
Similarities
Tisin, Rinonorm, Rinostop
Weight | 0.030 kg |
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Shelf life | 25 months. |
Conditions of storage | At a temperature not exceeding 25 ° C. Keep out of reach of children. |
Manufacturer | Pharmstandard-Leksredstva, Russia |
Medication form | dosed nasal spray |
Brand | Pharmstandard-Leksredstva |
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