Truxal, 50 mg 50 pcs.

Truxal is a neuroleptic, a derivative of thioxanthene. It has antipsychotic, pronounced sedative and moderate antidepressant effect.

Pharmacodynamics

The antipsychotic action of Truxal is associated with its blocking effect on dopamine receptors. Blockade of these receptors is also associated with antiemetic and analgesic properties of the drug. Truxal is able to block 5-NT₂ – receptors, α₁ – adrenoreceptors, and H₁ – histamine receptors, which determines its adrenoblocking, hypotensive and antihistamine properties.

Pharmacokinetics

The bioavailability of chlorprotixen with oral administration is approximately 12%. Chlorprotixen is rapidly absorbed from the intestine, the maximum concentration in blood serum is reached after 2 hours.

The elimination half-life is about 16 hours. Chlorprotixene penetrates the placental barrier and is excreted in small amounts with breast milk. Metabolites have no neuroleptic activity and are excreted in the feces and urine.

Indications

Truxal is a sedative neuroleptic with a wide range of indications that include:

Active ingredient

How to take, the dosage

Sychosis, including schizophrenia and manic states. Treatment begins with 50 to 100 mg/day, gradually increasing the dose until optimal effect is achieved, usually to 300 mg/day. In individual cases, the dose may be increased to 1200 mg/day. The maintenance dose is usually 100 to 200 mg/day.

The daily dose of Truxal is usually divided into 2 to 3 doses; given the pronounced sedative effect of Truxal, it is recommended that a smaller portion of the daily dose be given during the day and a larger portion in the evening.

Hangover withdrawal syndrome in alcoholism and drug addiction.

The daily dose, divided into 2 – 3 doses, is 500 mg. The course of treatment usually lasts 7 days. After the disappearance of withdrawal symptoms, the dose is gradually reduced. The maintenance dose of 15 to 45 mg/day helps to stabilize the condition, reducing the risk of another binge.

In elderly patients with hyperactivity, irritability, agitation, confusion is prescribed 15 – 90 mg/day. The daily dose is usually divided into 3 doses.

In children for correction of behavioral disorders Truxal is prescribed at the rate of 0.5 to 2 mg per 1 kg of weight.

Depressive states, neuroses, psychosomatic disorders. Truxal can be used for depression, especially combined with anxiety, tension, as an adjunct to antidepressant therapy or alone. Truxal may be prescribed for neurosis and psychosomatic disorders accompanied by anxiety and depressive disorders, up to 90 mg/day. The daily dose is usually divided into 2-3 doses. Because taking Truxal does not cause addiction or drug dependence, it can be used for a long time.

Insomnia. 15 – 30 mg in the evening 1 hour before sleep.

Pains. The ability of Truxal to potentiate the effects of analgesics can be used in the treatment of patients with pain. In these cases, Truxal is prescribed together with analgesics in doses from 15 to 300 mg.

Interaction

The CNS depressant effect of chlorprotixene may be enhanced with concomitant use of ethanol and ethanol-containing drugs, anesthetics, opioid analgesics, sedatives, hypnotics, neuroleptics.

The anticholinergic effect of chlorprotixen is enhanced with the simultaneous use of anticholinergic, antihistamines and antiparkinsonian agents.

The drug increases the effect of hypotensive agents.
Simultaneous use of chlorprotixen and adrenaline may lead to arterial hypotension and tachycardia.

The use of chlorprotixen leads to a decrease in the seizure threshold, which requires additional adjustment of the dose of anti-epileptic drugs in epileptic patients.

Chlorprotixen’s ability to block dopamine receptors reduces the effectiveness of levodopa.

Extrapyramid disorders may occur with concomitant use of phenothiazines, metoclopramide, haloperidol, reserpine.

Special Instructions

Truxal should be prescribed with caution in patients with epilepsy, parkinsonism, marked atherosclerosis of cerebral vessels, tendency to collapse, marked cardiovascular and respiratory failure, marked liver and renal function disorders, diabetes, prostatic hypertrophy.

The use of Truxal may lead to false positive results in urine immunobiological test for pregnancy, false increase in bilirubin levels in blood, changes in the QT interval on electrocardiogram.

During treatment with Truxal it is recommended to refrain from drinking alcohol and avoid excessive insolation.

Taking Truxal has a negative effect on activities requiring high speed of mental and physical reactions (e.g., driving vehicles, machine maintenance, working at heights, etc.).

Contraindications

Side effects

Sleepiness, tachycardia, dry mouth, increased sweating, or accommodation difficulties. These side effects, which usually occur at the beginning of therapy, often disappear as therapy continues. Orthostatic hypotension may occur, especially when using Truxal in high doses.

Dizziness, dysmenorrhea, skin rashes, constipation are rare. Extrapyramidal symptoms are particularly rare.

Single cases of decreased seizure threshold, transient benign leukopenia and hemolytic anemia have been described. With long-term use, especially with high doses the following may be observed: cholestatic jaundice, galactorrhea, gynecomastia, decreased potency and libido, increased appetite, increased body weight.

Overdose

Seecomptoms. Sleepiness, hypo- or hyperthermia, extrapyramidal symptoms, seizures, shock, coma.

Treatment. Symptomatic and supportive. Gastric lavage should be performed as soon as possible, the use of a sorbent is recommended. Measures should be taken to maintain respiratory and cardiovascular system activity.

Adrenaline should not be used as it may lead to a subsequent drop in blood pressure. Seizures can be controlled with diazepam and extrapyramidal symptoms with biperiden.

Similarities