Thiogamma, 600 mg 30 pcs

Tyogamma has hepatoprotective, hypoglycemic, detoxifying, hypolipidemic, hypocholesterolemic effect.

Thioctic acid (alpha-lipoic acid) is an endogenous antioxidant (binds free radicals) in the body is formed during the oxidative decarboxylation of alpha-ketoxylate.

As a coenzyme of mitochondrial multienzyme complexes is involved in oxidative decarboxylation of pyruvic acid and alpha-keto acids.

It helps to decrease the concentration of glucose in the blood and increase glycogen in the liver, as well as overcoming insulin resistance. By the nature of its biochemical action it is close to the B vitamins. Participates in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism, and improves liver function. It has hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect. It improves the trophism of neurons. The use of meglumine salt of thioctic acid in solutions for intravenous administration (which have neutral reaction) allows to decrease the side reactions.

Pharmacokinetics

In oral administration, it is quickly and completely absorbed from the gastrointestinal tract (ingestion with food reduces absorption). Time to reach maximum concentration – 40-60 minutes. Bioavailability is 30%.

It has the effect of “first passage” through the liver. The formation of metabolites occurs as a result of oxidation of the side chain and conjugation.

The volume of distribution is about 450 ml/kg. Thioctic acid and its metabolites are excreted by the kidneys (80-90%). The elimination half-life is 20-50 min. Total plasma clearance is 10-15 ml/min.

Indications

Polyneuropathy, Type 1 diabetes, Type 2 diabetes, Alcoholism

Diabetic polyneuropathy, alcoholic polyneuropathy.

Active ingredient

Thioctic acid

Composition

1 film-coated tablet contains:

the active ingredient:

thioctic acid – 600 mg;

excipients:

microcrystalline cellulose,

lactose,

p> talc,

silica colloidal dioxide,

hypromellose,

lactose monohydrate,

carboxylmethylcellulose sodium,

talk,

Simethicone,

Magnesium stearate,

MacroGol 600,

Sodium lauryl sulfate.

How to take, the dosage

Over the body is prescribed 600 mg once a day.

The tablets are taken without chewing, with a small amount of liquid.

Interaction

In concomitant use Tiogamma increases the effect of insulin and oral hypoglycemic agents.

Simultaneous use with ethanol may decrease the therapeutic effectiveness of thioctic acid.

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Special Instructions

Patients taking Thiogamma should refrain from drinking alcohol.

In patients with diabetes mellitus, continuous monitoring of blood glucose concentrations is necessary, especially in the initial phase of therapy.

In some cases, it is necessary to reduce the dose of insulin or oral hypoglycemic drug to avoid the development of hypoglycemia.

Contraindications

• High sensitivity to components of the drug Tiogamma.
• Pregnancy breastfeeding.
• Childhood (effectiveness and safety of use has not been established.

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Side effects

Ingestion may cause dyspepsia, including nausea and vomiting.

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Overdose

Symptoms:Nausea, vomiting, headache.

Treatment symptomatic. There is no specific antidote.

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Pregnancy use

The drug Tiogamma is contraindicated in pregnancy. If it is necessary to use the drug during lactation, breastfeeding should be stopped.

Teratogenic effect of thioctic acid was not revealed in experimental studies on animals. Similar studies in humans have not been conducted.

There are no data on excretion of thioctic acid with breast milk.

Similarities

Berlithione 300, Berlithione 300 oral, Thioctacid BV, Thiolepta, Octolipen, Berlithione, Thioctic acid