Epigrix, 15 mg/ml 1 ml 10 pcs

How to take, the dosage

Intramuscularly or subcutaneously.

The doses and duration of treatment are determined individually depending on the severity of the disease.

Diseases of peripheral nervous system

• Mono- and polyneuropathies of various genesis: subcutaneously and intramuscularly 5-15 mg 1-2 times daily, 10-15 days course (in severe cases – up to 30 days); then the use of ipidacrine tablets is changed.

• Miasthenia and myasthenic syndrome: subcutaneously and intramuscularly 5-30 mg 1?3 times a day; then switch to taking ipidacrine in tablets. The total course of treatment is 1? 2 months. If necessary, treatment can be repeated several times with a break between courses of 1-2 months.

Diseases of the central nervous system

• Bulbar paralysis and paresis: subcutaneously and intramuscularly 5-15 mg 1-2 times a day, course 10-15 days; then switch to taking ipidacrine in tablets.

• Rehabilitation for organic lesions of the CNS: intramuscularly 10-15 mg 1? 2 times a day, the course of up to 15 days; then the use of ipidacrine in tablets is changed.

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Interaction

Ipidacrine attenuates the inhibitory effect on neuromuscular transmission and excitation along the peripheral nerves of local anesthetics, aminoglycosides and potassium chloride.

The sedative effect of CNS-depressant drugs, including ethanol, as well as the effect of other cholinesterase inhibitors and m-cholinomimetic substances is increased under the influence of ipidacrine.

In concomitant use of other cholinergic drugs, ipidacrine increases the risk of cholinergic crisis in myasthenic patients.

The beta-adrenolytic agents increase the severity of bradycardia caused by ipidacrine.

Cerebrolysin potentiates the effect of ipidacrine.

Alcohol increases the unwanted side effects of ipidacrine.

Ipidacrine can be used in combination with nootropic drugs.

Special Instructions

Influence on driving and operating machinery

Ipidacrine may have a sedative effect, so patients who are exposed to this effect when using the drug should exercise caution when driving and operating machinery./p>

Precautionary measures for use

There are no systematic data on use in children.

Alcohol, which increases the side effects of ipidacrine, should be avoided during treatment.

Ipidacrine may worsen the course of epilepsy, and also increase the negative effects of alcohol on the body.

In depressed patients, ipidacrine may worsen the symptoms of depression.

Because of the possible risk of bradycardia when using ipidacrine, heart activity should be monitored.

Contraindications

Do not use in:

• Epilepsy.

• Hypersensitivity to ipidacrine and/or any of the excipients of the drug.

• Angina pectoris.

• Extrapyramidal disorders with hyperkinesias.

• Severe bradycardia.

• Bronchial asthma.

• Vestibular disorders.

• Aggravation of gastric or duodenal ulcer.

• Mechanical obstruction of the intestine or urinary tract.

• Pregnancy and the period of breastfeeding.

• Children under 18 years of age (no systematic safety data on use).

With caution in: gastric and duodenal ulcer, thyrotoxicosis, cardiovascular disease, and patients with a history of obstructive respiratory disease or acute respiratory conditions.

With caution:

• lactase deficiency;
• lactose intolerance;
• lactose/isomaltose malabsorption syndrome because the drug contains lactose.

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Side effects

Ipidacrine is usually well tolerated. Side effects are mainly related to stimulation of m-cholinoreceptors.

The following side effects of ipidacrine are classified by system and organ group with the frequency of occurrence: Frequent (≥1/100 to infrequent (≥1/1000 to rare (≥1/10,000 to

Gastrointestinal disorders

Frequent: hypersalivation, nausea.

Infrequent: vomiting.

Rarely: diarrhea, epigastric pain.

Unknown: dyspepsia.

Nervous system disorders

Infrequent: dizziness, headaches, drowsiness, muscle spasm, weakness.

Disorders with cardiac function

Often: palpitations, bradycardia.

Visual disorders

Unknown: miosis.

Respiratory system, chest and mediastinum disorders

Infrequent: increased bronchial secretion, bronchospasm.

Skeletal and muscular system and connective tissue disorders

Unknown: tremors, cramps, increased uterine tone.

Skin and subcutaneous tissue disorders

Often: sweating.

Infrequent: allergic reactions (itching, rashes), usually with high doses of the drug.

General disorders and reactions at the site of administration

Unknown: hypothermia, chest pain, jaundice.

If any of the listed side effects occur, or if a side effect not mentioned in the instructions occurs, a physician should be consulted.

Overdose

Symptoms: In severe overdose, cholinergic crisis may develop (decreased appetite, bronchospasm, lacrimation, increased sweating, constriction of pupils, nystagmus, increased peristalsis of the gastrointestinal tract, spontaneous defecation and urination, vomiting, jaundice, bradycardia, intracardiac conduction disorders, arrhythmias, arterial hypotension, restlessness, anxiety, agitation, fear, ataxia, seizures, coma, speech disorders, drowsiness, general weakness).

Treatment: symptomatic therapy, use m-cholinolytic agents (including atropine, cyclodol, methacin).

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Similarities

Neuromidine, Axamon