Truxal, 50 mg 50 pcs.

Truxal is a neuroleptic, a derivative of thioxanthene. It has antipsychotic, pronounced sedative and moderate antidepressant effect.

Pharmacodynamics

The antipsychotic action of Truxal is associated with its blocking effect on dopamine receptors. Blockade of these receptors is also associated with antiemetic and analgesic properties of the drug. Truxal is able to block 5-NT₂ – receptors, α₁ – adrenoreceptors, and H₁ – histamine receptors, which determines its adrenoblocking, hypotensive and antihistamine properties.

Pharmacokinetics

The bioavailability of chlorprotixen with oral administration is approximately 12%. Chlorprotixen is rapidly absorbed from the intestine, the maximum concentration in blood serum is reached after 2 hours.

The elimination half-life is about 16 hours. Chlorprotixene penetrates the placental barrier and is excreted in small amounts with breast milk. Metabolites have no neuroleptic activity and are excreted in the feces and urine.

Indications

Mental Disorders, Manic Depressive Psychosis, Delirium, Schizophrenia, Hangover, Depression, Neurosis, Irritability, Insomnia, Anxiety

Truxal is a sedative neuroleptic with a wide range of indications that include:

• Psychosis, including schizophrenia and manic states occurring with psychomotor agitation, agitation and anxiety.
• Hangover withdrawal syndrome in alcoholism and drug addiction.
• Hyperactivity, irritability, agitation, confusion in elderly patients.
• Depressive states, neuroses, psychosomatic disorders.
• Besomnia.
• Pains (in combination with analgesics).

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Active ingredient

Chlorprotixen

How to take, the dosage

Sychosis, including schizophrenia and manic states. Treatment begins with 50 to 100 mg/day, gradually increasing the dose until optimal effect is achieved, usually to 300 mg/day. In individual cases, the dose may be increased to 1200 mg/day. The maintenance dose is usually 100 to 200 mg/day.

The daily dose of Truxal is usually divided into 2 to 3 doses; given the pronounced sedative effect of Truxal, it is recommended that a smaller portion of the daily dose be given during the day and a larger portion in the evening.

Hangover withdrawal syndrome in alcoholism and drug addiction.

The daily dose, divided into 2 – 3 doses, is 500 mg. The course of treatment usually lasts 7 days. After the disappearance of withdrawal symptoms, the dose is gradually reduced. The maintenance dose of 15 to 45 mg/day helps to stabilize the condition, reducing the risk of another binge.

In elderly patients with hyperactivity, irritability, agitation, confusion is prescribed 15 – 90 mg/day. The daily dose is usually divided into 3 doses.

In children for correction of behavioral disorders Truxal is prescribed at the rate of 0.5 to 2 mg per 1 kg of weight.

Depressive states, neuroses, psychosomatic disorders. Truxal can be used for depression, especially combined with anxiety, tension, as an adjunct to antidepressant therapy or alone. Truxal may be prescribed for neurosis and psychosomatic disorders accompanied by anxiety and depressive disorders, up to 90 mg/day. The daily dose is usually divided into 2-3 doses. Because taking Truxal does not cause addiction or drug dependence, it can be used for a long time.

Insomnia. 15 – 30 mg in the evening 1 hour before sleep.

Pains. The ability of Truxal to potentiate the effects of analgesics can be used in the treatment of patients with pain. In these cases, Truxal is prescribed together with analgesics in doses from 15 to 300 mg.