Tranexam, 50 mg/ml 5 ml 10 pcs

Tranexamic has a hemostatic, anti-inflammatory, anti-allergic effect.

Tranexamic acid is an antifibrinolytic agent specifically inhibiting the activation of profibrinolysin (plasminogen) and its conversion into fibrinolysin (plasmin).

It has local and systemic hemostatic action in bleeding associated with increased fibrinolysis as well as anti-inflammatory, anti-allergic, anti-infective and

anti-tumor action due to suppression of formation of kinins and other active peptides involved in allergic and inflammatory reactions.

The intrinsic analgesic activity of tranexamic acid was confirmed in the experiment, as well as the supersumptive andotensive effect with respect to the analgesic activity of opiates.

Pharmacokinetics

The distribution in tissues is relatively uniform (exception is cerebrospinal fluid, where the concentration is 1/10 of the plasma concentration); penetrates through the placental and blood-brain barrier, into breast milk (about 1% of the concentration in maternal plasma).

Detected in seminal fluid, where it reduces fibrinolytic activity, but does not affect sperm migration. The initial volume of distribution is 9-12 liters.

The binding to plasma proteins (profibrinolysin) is less than 3%. In the blood about 3% is bound to protein (plasminogen).

The concentration in cerebrospinal fluid is 1/10 of plasma. Total renal clearance is equal to plasma clearance. Antifibrinolytic concentration in various tissues persists for 17 hours, in plasma – up to 7-8 hours.

A small part is metabolized. The concentration-time curve has a three-phase shape with a half-life of -2 hours in the terminal phase. Total renal clearance is equal to plasma clearance (7 l/h).

Extracted by the kidneys (main route – glomerular filtration) – more than 95% unchanged in the first 12 hours.

Two metabolites of tranexamic acid have been identified: N-acetylated and deaminated derivatives. There is a risk of cumulation of tranexamic acid in impaired renal function.

Indications

Active ingredient

Composition

1 liter of solution for intravenous administration contains

Active substance:

Tranexamic acid 50 g;

Auxiliary substances:

Water for injection – up to 1 liter

How to take, the dosage

Intravenously by drip or stream slowly; infusion rate 1 ml/min (50 mg/min). Rapid intravenous administration should be avoided!

Adult patients:

If prolonged (more than 48 hours) hemostatic therapy is necessary, the use of tranexamic acid preparations in tablet form is recommended.

Children over 1 year

The experience with tranexamic acid preparations in children is limited. The recommended dose of the drug in the treatment of bleeding due to local and generalized fibrinolysis is 20 mg/kg/day.

The use of the drug in special patient groups

Kidney function impairment

In patients with mild to moderate impaired renal excretory function, adjustment of the dose and frequency of tranexamic acid is necessary:

Interaction

Special Instructions

Contraindications

Side effects

Pregnancy use

Similarities