Ferrum Lek, 50 mg/ml 2 ml 5 pcs

How to take, the dosage

Intramuscularly (only).

Before administering the first therapeutic dose of the drug, each patient should be given a test dose of 1/4-1/2 ampoule of Ferrum Lek (25-50 mg of iron) for an adult and half the daily dose for a child. If there are no adverse reactions, the remaining part of the daily dose can be administered within 15 minutes.

The doses of Ferrum Lek must be selected individually, according to the total iron deficiency, which is calculated according to the following formula:

Total iron deficiency = body weight (kg) × (estimated hemoglobin level (g/L) – real hemoglobin level (g/L) × 0.24) + deposited iron (mg)

Body weight to 35 kg: Estimated hemoglobin level = 130 g/L and deposited iron = 15 mg/kg

Body weight over 35 kg: Estimated hemoglobin level = 150 g/L and deposited iron = 500 mg

Factor 0.24 = 0.0034 × 0.07 × 1000

(Iron content = 0.34%; total blood volume = 7% of body weight; factor 1000 = conversion from g to mg).

Example

Patient body weight: 70 kg

Real hemoglobin concentration: 80 g/L

Total iron deficiency = (150 – 80) × 0.24 + 500 = 1,700 mg of iron

Total number of vials of Ferrum Lek to be administered = Total iron deficiency (mg) / 100 mg

Calculation of the total number of vials of Ferrum Lek to be administered, based on the real concentration of haemoglobin and body weight

The calculation of the total number of vials of Ferrum Lek to be administered./p>

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If the required dose of Ferrum Lek exceeds the maximum daily dose, the drug should be administered fractionally (over several days).

If 1-2 weeks after the start of treatment the hematologic parameters do not change, the diagnosis should be clarified.

Calculation of the total dose to compensate for iron due to blood loss

The amount of drug needed to compensate for posthemorrhagic iron deficiency is calculated using the following formula.

If the amount of blood loss is known: administration of 200 mg intramuscularly (2 ampoules of Ferrum Lek) leads to increase of the hemoglobin level which is equivalent to 1 unit of blood (400 ml of blood with hemoglobin content of 150 g/l).

The iron to be replenished (mg) = number of blood units lost × 200 or the required number of ampoules of Ferrum Lek = number of blood units lost × 2.

If the final hemoglobin level is known, the following formula must be used, taking into account that deposited iron does not need to be reimbursed.

The iron that should be reimbursed (mg) = body weight (kg) × (estimated hemoglobin level (g/L) – real hemoglobin level (g/L) × 0.24.

A patient with a body weight of 60 kg and a hemoglobin deficiency of 10 g/l should have 150 mg of iron, which is 1.5 ampoules of Ferrum Lek.

Standard doses

In children: 0.06 ml/kg/day (3 mg of iron/kg/day).

Adults: 1-2 ampoules of Ferrum Lek (100-200 mg of iron), depending on hemoglobin levels.

Maximum daily doses

In children: 0.14 ml/kg/day (7 mg of iron/kg/day).

Adults: 4 ml (2 ampoules) per day.

Interaction

Do not use concomitantly with oral iron-containing drugs.

The concomitant use of ACE inhibitors may increase the systemic effects of parenteral iron drugs.

Special Instructions

Use only in a hospital environment.

When prescribing Ferrum Lek it is necessary to perform laboratory tests: general clinical blood test and determination of serum ferritin; it is necessary to exclude iron absorption disorders.

Ferrum Lec is only for intramuscular administration.

Injection deep into the gluteal muscle (5-6 cm long needle) is mandatory, as well as tissue displacement when inserting the needle and tissue compression after removal of the needle; injected alternately in the right and left gluteal muscles.

The opened ampoule must be used immediately.

The contents of Ferrum Lekne ampoules should be mixed with other medications.

The treatment with oral forms of iron-containing drugs should not be started earlier than 5 days after the last injection of Ferrum Lecne.

In case of improper storage of the drug, precipitation may occur, the use of these ampoules is unacceptable.

Contraindications

• high sensitivity to the drug components;
• excess iron in the body (hemochromatosis, hemosiderosis);
• .Impaired iron utilization mechanisms (lead anemia, sideroachrestic anemia, thalassemia);
• anemias not related to iron deficiency (e.g. hemolytic, megaloblastic, caused by cyanocobalamin deficiency).
• Pregnancy first trimester;
• Osler-Randu-Weber syndrome;
• infectious kidney diseases in the acute stage;
• uncontrolled hyperparathyroidism;
• decompensated cirrhosis of the liver;
• infectious hepatitis.

With caution: childhood (under 4 months).

Side effects

• Arterial hypotension,
• joint pain,
• increased lymph nodes,
• increased body temperature,
• headache,

malaise,

dyspepsia (nausea, puffiness).headache,

• dizziness,
• malaise,
• dyspepsia (nausea, vomiting);
• very rarely – allergic or anaphylactic reactions.

Inappropriate injection technique may cause staining of the skin, pain, and inflammation at the injection site.

Overdose

Symptoms from the drug: iron overdose can lead to acute iron overload and hemosiderosis.

Pregnancy use

The drug is contraindicated in the first trimester of pregnancy. In II and III trimesters and during breastfeeding the drug may be used only if the expected benefits to the mother exceed the potential harm to the fetus or infant.