Tantum Verde, 240 ml solution

Benzidamine is a non-steroidal anti-inflammatory drug, belongs to the group of indazoles. It has anti-inflammatory and local analgesic effect, has antiseptic action against a wide range of microorganisms. Mechanism of action of the drug is related to cell membranes stabilization and inhibition of prostaglandins synthesis.

Benzidamin produces antibacterial and specific antimicrobial action due to rapid penetration through the membranes of microorganisms with subsequent damage of cellular structures, disruption of metabolic processes and cell lysosomes. It has antifungal action against Candida albicans. Causes structural

modifications of cell wall of fungi and their metabolic chains, thus preventing their reproduction, which was the basis for benzidamine application in inflammatory processes in the oral cavity, including infectious etiology.

Indications

Symptomatic treatment of pain syndrome of inflammatory diseases of the oral cavity and ENT organs (of various etiologies):

– gingivitis, glossitis, stomatitis (including after radiation and chemotherapy);
– pharyngitis, laryngitis, tonsillitis;
– candidiasis of the oral mucosa (as part of combination therapy);
– calculous inflammation of the salivary glands;
– after surgical interventions and injuries (tonsillectomy, jaw fractures);
– after treatment and tooth extraction;
– periodontal disease.

For infectious and inflammatory diseases requiring systemic treatment, it is necessary to use Tantum® Verde as part of combination therapy.

Pharmacological effect

Benzidamine is a non-steroidal anti-inflammatory drug that belongs to the indazoles group. It has an anti-inflammatory and local analgesic effect, and has an antiseptic effect against a wide range of microorganisms. The mechanism of action of the drug is associated with the stabilization of cell membranes and inhibition of prostaglandin synthesis.

Benzidamine has an antibacterial and specific antimicrobial effect due to rapid penetration through the membranes of microorganisms with subsequent damage to cellular structures, disruption of metabolic processes and cell lysosomes. It has an antifungal effect against Candida albicans. Calls structural

modification of the cell wall of fungi and their metabolic chains, thus preventing their reproduction, which was the basis for the use of benzydamine for inflammatory processes in the oral cavity, including infectious etiology.

Active ingredient

Benzydamine

Composition

Per 100 ml of solution for topical use 0.15%:

active ingredient:

benzydamine hydrochloride 0.15 g;

excipients: ethanol 96%, glycerol (glycerin), methyl parahydroxybenzoate, menthol flavor, saccharin, sodium bicarbonate, polysorbate 20, quinoline yellow dye 70% (E 104), patent blue dye 85% (E 131), purified water.

Pregnancy

Tantum® Verde should not be used during pregnancy or breastfeeding.

Contraindications

hypersensitivity to benzydamine or other components of the drug;
children’s age up to 12 years

Side Effects

World Health Organization (WHO) side effect frequency classification:
very often – ≥1/10;
often – from ≥1/100 to <1/10; uncommon - from ≥1/1000 to <1/100; rarely - from ≥1/10000 to <1/1000; very rarely - <1/10000; frequency unknown—cannot be estimated from available data. Within each group, adverse effects are presented in decreasing order of severity.Local reactions: rarely – dry mouth, burning sensation in the oral cavity; frequency unknown – feeling of numbness in the mouth.Allergic reactions: uncommon – photosensitivity; rarely – hypersensitivity reactions, skin rash, itching; very rarely – angioedema, laryngospasm; frequency unknown – anaphylactic reactions.If any of the side effects indicated in the instructions worsen, or any other side effects not listed in the instructions are noted, you should immediately inform your doctor.

Interaction

No interaction studies have been conducted with other drugs.

Overdose

Currently, no cases of overdose of Tantum® Verde have been reported.

Clinical pharmacology

When applied topically, the drug is well absorbed through the mucous membranes and penetrates into inflamed tissues; it is found in the blood plasma in quantities insufficient to obtain systemic effects.

Excretion of the drug occurs mainly by the kidneys, in the form of inactive metabolites or conjugation products.

Storage conditions

Does not require special storage conditions.

Keep out of the reach of children.

Shelf life

4 years.

Manufacturer

Aziende Chimique Riunite Angelini Francesco A.C.R.A., Italy