Suprilamin, tablets 25 mg 20 pcs

Pharmacotherapeutic group:

anti-allergic agent – H1-histamine receptor blocker

ATX code: R06AC03

Pharmacological properties

Pharmacodynamics

Chloropyramine, a chlorinated analog of tripelenamine (pyribenzamine), is a first-generation antihistamine drug belonging to the group of ethylenediamine antihistamines.

A blocker of H1-histamine receptors, it has antihistamine and m-cholin-blocking effects. This drug also acts on smooth muscles, on capillary permeability and on the central nervous system (CNS).

When taken orally, the effect occurs as early as 15-30 minutes, the maximum effect develops within 1 hour and lasts for about 3-6 hours.

Pharmacokinetics

Intake

In oral administration, it is almost completely absorbed from the gastrointestinal tract (GIT). The therapeutic effect of chloropyramine develops within 15-30 minutes after oral administration, reaches its maximum within the first hour after administration and lasts for at least 3-6 hours.

Distribution

It is well distributed in the body, including the CNS.

Metabolism

Intensively metabolized in the liver.

Elimination

Extracted mainly by the kidneys as metabolites.

Particular patient populations

Children and adolescents

The drug is eliminated faster in children than in adult patients.

Patients with impaired liver function

In patients with impaired liver function, the metabolism of chloropyramine is decreased, so the dose of the drug may be reduced.

Patients with impaired renal function

In patients with impaired renal function, the excretion of chloropyramine is decreased, so the dose of the drug may be reduced.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

The use of chloropyramine in the late evening hours may worsen symptoms of gastroesophageal reflux disease.

In combination with ototoxic drugs, chloropyramine may mask early signs of ototoxicity.

Hepatic and renal disease may require modification (reduction) of the drug dose, and therefore, the patient should inform the physician if he or she has hepatic and renal disease.

Because of its anticholinergic and sedative effect, chloropyramine should be prescribed with caution in elderly patients, patients with liver dysfunction, cardiovascular disease, closed-angle glaucoma, urinary retention and prostatic hyperplasia.

Chloropyramine may increase the effects of alcohol on the CNS, therefore, drinking alcoholic beverages while taking the drug is prohibited.

Long-term use of antihistamines may lead to disorders of the blood system and hematopoiesis (leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia). If during long-term use unexplained increase in body temperature, laryngitis, pale skin, jaundice, formation of mouth ulcers, appearance of bruises, unusual and prolonged bleeding it is necessary to conduct a clinical blood test with determination of the number of enzyme elements. If the test results indicate a change in blood count, the drug should be discontinued.

Each tablet contains 130 mg of lactose monohydrate. The drug is contraindicated in patients with lactase deficiency, lactose intolerance, glucose/galactose malabsorption.

The drug, especially in the initial period of treatment, may cause drowsiness, fatigue and dizziness. Therefore, during the initial period, the duration of which is determined individually, it is forbidden to drive vehicles or perform work associated with an increased risk of accidents. After that the degree of restriction to drive vehicles and work with mechanisms should be determined for each patient individually by a physician.

Contraindications

Hypersensitivity to chloropyramine and other components of the drug, acute onset of bronchial asthma, lactose intolerance, lactase deficiency or glucose-galactose malabsorption, pregnancy, lactation, children under 3 years (for this dosage form).

Closed-angle glaucoma, urinary retention, prostatic hyperplasia, impaired liver and/or renal function, cardiovascular disease elderly patients.

Side effects

Overdose

Pregnancy use

Similarities