Bactroban, nasal ointment 2% 3 g

Bactroban is a broad-spectrum antibiotic for topical and external use.

It suppresses isoleucine transfer RNA synthetase, which leads to cessation of protein synthesis in the bacterial cell. Due to the specific mechanism of action and the unique chemical structure, mupirocin shows no cross-resistance with other antibiotics (if the drug is used correctly, the risk of resistant strains is low).

Pharmacodynamics

In minimal inhibitory concentrations it has bacteriostatic and in higher concentrations it has bactericidal properties. Spectrum of antibacterial activity in vitro:

• Gram-positive aerobes: Staphylococcus aureus (including strains resistant to methicillin and producing beta-lactamases), Staphylococcus epidermidis and other coagulase-negative Staphylococcus spp., Streptococcus spp. ;
• Graham-negative anaerobes: Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Branhamella catarrhalis, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, Bordetella pertussis;
• insensitive: Corynebacterium spp., species of the family Enterobacteriaceae, Gram-negative non-fermenting bacilli, Micrococcus, anaerobes.

Pharmacokinetics

It is characterized by poor permeability through the intact skin. In case of absorption through damaged skin, it is metabolized to microbiologically inactive monic acid and is rapidly excreted by the kidneys.

Indications

Nasal sinus (rhinitis)

Carrying Staphylococcus aureus (including multiresistant and methicillin-resistant strains of Staphylococcus aureus).

Active ingredient

Mupirocin

Composition

Active ingredient: mupirocin 2%;

Auxiliary substances: paraffin base with glycerin ester additive.

How to take, the dosage

Intranasally. Intranasal ointment: Apply to the inner surface of the nostrils 2-3 times a day for 5-7 days.

Outerine ointment: For adults, children and elderly patients apply a small amount to the affected area of skin 2-3 times a day; if necessary, an aseptic dressing should be applied; the course of treatment is up to 10 days.

In case of hepatic insufficiency the standard dosage is used.

Bactroban ointment should not be combined with other drugs because of the risk of dilution, reduced antibacterial activity and stability.

Special Instructions

Wash hands thoroughly after application to the skin. Prolonged administration of Bactroban ointment may lead to excessive growth of insensitive microorganisms.

No adverse effects on the ability to drive/machine have been observed.

Contraindications

Hypersensitivity to any component of the ointment.

With caution: during pregnancy and lactation.

Side effects

• very rarely – itching, burning, burning, and dry skin at the application site;
• frequently – skin allergic reactions;
• in rare cases – systemic allergic reactions; rhinitis (when using intranasal ointment).

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Pregnancy use

Use with caution due to insufficient data confirming the safety of the drug during these periods.

Similarities

Supirocin