Sanofi Chlorprotixen, 50 mg 50 pcs

Antipsychotic agent (neuroleptic), derivative of thioxanthene. It has antipsychotic, antidepressant, sedative, antiemetic effects, has alpha-adrenoblocking activity.

It is believed that the antipsychotic action is associated with blockade of postsynaptic dopamine receptors in the brain. Antiemetic action is associated with blockade of the chemoreceptor trigger zone of the medulla oblongata.

The sedative effect is caused by indirect weakening of the activity of the reticular system of the brain stem. It suppresses release of most hormones of the hypothalamus and pituitary gland.

But as a result of the blockade of the prolactin inhibitory factor, which inhibits the release of prolactin from the pituitary gland, the concentration of prolactin increases.

The thioxanthenes are similar to the piperazine derivatives of phenothiazine in their chemical structure and pharmacological properties.

Indications

Psychosis and psychotic conditions accompanied by anxiety, fear, psychomotor agitation, aggressiveness, including. In depressive-paranoid, circular schizophrenia, in simple slow-onset schizophrenia with psychopath-like and neurosis-like symptoms and in other mental diseases;

discirculatory encephalopathy, craniocerebral trauma (in combined therapy), alcohol delirium; sleep disorders in somatic diseases;

The need for long-term therapy of states of agitation and anxiety, psychosomatic, neurotic and behavioral disorders in children;

Convulsive cough, gastrointestinal spastic conditions;

premedication;

dermatoses accompanied by persistent itching;

allergic reactions.

Active ingredient

Composition

1 film-coated tablet contains:

The active ingredient:

Chlorprotixene hydrochloride 50 mg,

Ancillary substances:

Corn starch – 37.5 mg,

lactose monohydrate – 135 mg,

sucrose – 20 mg,

calcium stearate – 3.75 mg,

talc – 3.75 mg.

Composition of the film coating:

Hypromellose 2910/5 – 3.6594 mg, macrogol 6000 – 0.1333 mg, macrogol 300 – 0.9166 mg, talc – 2.4194 mg, titanium dioxide – 0.3423 mg, iron oxide yellow dye – 0.029 mg.

How to take, the dosage

Psychosis, including schizophrenia and manic states.

Treatment begins with 50-100 mg/day, gradually increasing the dose until optimal effect is achieved, usually to 300 mg/day. In individual cases, the dose may be increased to 1200 mg/day. The maintenance dose is usually 100-200 mg/day. The daily dose of Chloroprotixen Zentiva is usually divided into 2-3 doses; given the pronounced sedative effect of Chloroprotixen Zentiva, it is recommended that a smaller portion of the daily dose be given during the daytime and a larger portion in the evening.

Hangover withdrawal syndrome in alcoholism and drug addiction.

The daily dose, divided into 2-3 doses, is 500 mg. The course of treatment usually lasts 7 days. After withdrawal symptoms disappear, the dose is gradually reduced. The maintenance dose of 15-45 mg/day helps to stabilize the condition, reducing the risk of another binge.

In elderly patients with hyperactivity, irritability, agitation, confusion, 15-90 mg/day is prescribed. The daily dose is usually divided into 3 doses.

In children for correction of behavioral disorders, Chlorprotixen Zentiva is prescribed at the rate of 0.5-2 mg/kg body weight.

Depressive states, neuroses, psychosomatic disorders.

Chloroprotixen Zentiva may be used for depression, especially when combined with anxiety, tension, as an adjunct to antidepressant therapy or alone. Chlorprotixen Zentiva may be prescribed for neurosis and psychosomatic disorders accompanied by anxiety and depressive disorders up to 90 mg/day. The daily dose is usually divided into 2-3 doses. As taking Chlorprotixen Zentiva does not cause addiction or dependence, it can be used for a long time.

Insomnia. By 15 – 30 mg in the evening 1 hour before sleep.

Pain. The ability of Chlorprotixen Zentiva to potentiate the effects of analgesics can be used in the treatment of patients with pain. In these cases, Chlorprotixen Zentiva is prescribed together with analgesics in doses from 15 to 300 mg.

Interaction

The CNS depressant effect of chlorprotixene may be enhanced with concomitant use of ethanol and ethanol-containing drugs, anesthetics, opioid analgesics, sedatives, hypnotics, neuroleptics.

The anticholinergic effect of chlorprotixen is increased with the simultaneous use of anticholinergic, antihistamine and antiparkinsonian agents.

The drug increases the effect of hypotensive drugs.

The simultaneous use of chlorprotixen and adrenaline may lead to arterial hypotension and tachycardia.
The use of chlorprotixen leads to a decrease in the seizure activity threshold, which requires additional adjustment of the dose of antiepileptic drugs in patients with epilepsy.

Chlorprotixen’s ability to block dopamine receptors reduces the effectiveness of levodopa.

Extrapyramid disorders may occur with concomitant use of phenothiazines, metoclopramide, haloperidol, reserpine.

Special Instructions

Chloroprotixen should be used with caution in patients with epilepsy, parkinsonism, severe atherosclerosis of cerebral vessels, tendency to collapse, severe cardiovascular and respiratory failure, severe liver and renal function disorders, diabetes, prostatic hypertrophy.

The use of Chlorprotixen may lead to false positive results in urine immunobiological test for pregnancy, false elevation of bilirubin level in blood, changes in QT interval on electrocardiogram.

At the time of treatment with the drug, it is recommended to refrain from drinking alcohol and to avoid excessive insolation.

Influence on driving and operating machinery

The administration of Chlorprotixen has a negative effect on activities requiring high speed of mental and physical reactions (such as driving vehicles, operating machinery, working at heights, etc.).

Contraindications

Side effects

Sleepiness, tachycardia, dry mouth, increased sweating, and difficulty with accommodation. These side effects, which usually occur at the beginning of therapy, often disappear as therapy continues.

Orthostatic hypotension may occur, especially when using Chlorprotixen in high doses.

Dizziness, dysmenorrhea, skin rashes, constipation are rare. Extrapyramidal symptoms are particularly rare.

A single case of decreased seizure threshold, transient benign leukopenia, and hemolytic anemia has been described.

In long-term use, especially in high doses the following may be observed: cholestatic jaundice, galactorrhea, gynecomastia, decreased potency and/or libido, increased appetite, increased body weight.

Overdose

Symptoms. Drowsiness, hypo- or hyperthermia, extrapyramidal symptoms, seizures, shock, coma.

Treatment. Symptomatic and supportive.

Gastric lavage should be performed as soon as possible, the use of a sorbent is recommended.

Measures should be taken to maintain respiratory and cardiovascular system activity.

Adrenaline should not be used as it may cause a subsequent drop in blood pressure.

Convulsions can be controlled with diazepam and extrapyramidal disorders with biperiden.

Pregnancy use

Chlorprotixen should not, if possible, be prescribed to pregnant women and during breastfeeding.

Similarities